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Prospective evaluat...
Prospective evaluation of coronary FLOW reserve and molecular biomarkers in patients with established coronary artery disease the PROFLOW-trial : Cross-sectional evaluation of coronary flow reserve
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- Haraldsson, Inger (författare)
- Sahlgrenska University Hospital,Sahlgrenska Academy
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- Gan, Li Ming (författare)
- Sahlgrenska University Hospital,AstraZeneca, Sweden,Sahlgrenska Academy
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- Svedlund, Sara (författare)
- Sahlgrenska University Hospital,Sahlgrenska Academy
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- Torngren, Kristina (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups
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- Westergren, Helena U. (författare)
- AstraZeneca, Sweden
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- Redfors, Björn (författare)
- Sahlgrenska Academy,Sahlgrenska University Hospital
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- Lagerström-Fermér, Maria (författare)
- AstraZeneca, Sweden
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- Angerås, Oskar (författare)
- Sahlgrenska Academy,Sahlgrenska University Hospital
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- Råmunddal, Truls (författare)
- Sahlgrenska Academy,Sahlgrenska University Hospital
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- Petursson, Petur (författare)
- Sahlgrenska University Hospital,Sahlgrenska Academy
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- Odenstedt, Jacob (författare)
- Sahlgrenska Academy,Sahlgrenska University Hospital
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- Albertsson, Per (författare)
- Sahlgrenska University Hospital,Sahlgrenska Academy
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- Erlinge, David (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups
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- Omerovic, Elmir (författare)
- Sahlgrenska Academy,Sahlgrenska University Hospital
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(creator_code:org_t)
- 2019
- 2019
- Engelska.
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Ingår i: Vascular Health and Risk Management. - 1178-2048. ; 15, s. 375-384
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background: Survivors of myocardial infarction (MI) are at high risk of new major adverse cardiovascular events (MACE). Coronary flow reserve (CFR) is a strong and independent predictor of MACE. Understanding the prevalence of impaired CFR in this patient group and identifying risk markers for impaired CFR are important steps in the development of personalized and targeted treatment for high-risk individuals with prior MI. Methods: PROFLOW is a prospective, exploratory, cross-sectional open study. We used information from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) to identify high-risk patients with a history of type-1 MI. We measured CFR non-invasively in a left anterior descending artery (LAD) using transthoracic Doppler echocardiography. Coronary flow velocity was measured at rest and at maximal flow after induction of hyperemia by intravenous infusion of adenosine (140 μg/kg/min). Independent predictors of CFR were assessed with multiple linear regression. Results: We included 619 patients. The median age was 69 (IQR 65–73), and 114 (18.4%) were women. Almost one-half of the patients, 285 (46.0%) had the multi-vessel disease, and 147 (23.7%) were incompletely revascularized. The majority were on optimal standard treatment eg ASA (93.1%), statins (90.0%), ACEI/ARB (82.6%) and beta-blockers (80.8%). The majority, 547 (88.4%) had no angina pectoris, and 572 (92.2%) were in NYHA class I. Evaluation of CFR was possible in 611 (98.7%) patients. Mean CFR was 2.74 (±0.79 (mean ± SD)). A substantial number of patients (39.7%) had CFR ≤2.5. In a multiple linear regression model age, dyslipidemia, smoking, hypertension, body mass index, incomplete revascularization, and treatment with angio-tensin receptor blockers were independent predictors of CFR. Conclusion: In this high-risk group of patients with prior MI, the prevalence of impaired CFR was high. Further risk stratification with CFR in addition to traditional cardiovascular risk factors may improve predictive accuracy for future MACE in this patient population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Coronary flow reserve
- Doppler echocardiography
- Myocardial infarction
- Prognosis
- Secondary prevention
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Haraldsson, Inge ...
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Gan, Li Ming
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Svedlund, Sara
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Torngren, Kristi ...
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Westergren, Hele ...
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Redfors, Björn
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visa fler...
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Lagerström-Fermé ...
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Angerås, Oskar
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Råmunddal, Truls
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Petursson, Petur
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Odenstedt, Jacob
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Albertsson, Per
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Erlinge, David
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Omerovic, Elmir
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Vascular Health ...
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Lunds universitet