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Impact of prior the...
Impact of prior therapy on the efficacy and safety of oral ixazomib-lenalidomide-dexamethasone vs. placebo-lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma in TOURMALINE-MM1
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- Mateos, María-Victoria (författare)
- University Hospital of Salamanca
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- Masszi, Tamas (författare)
- Semmelweis University
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- Grzasko, Norbert (författare)
- Medical University of Lublin
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- Hansson, Markus (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Sandhu, Irwindeep (författare)
- University of Alberta
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- Pour, Ludek (författare)
- Masaryk University
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- Viterbo, Luísa (författare)
- Instituto Português de Oncologia do Porto Francisco Gentil (IPO)
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- Jackson, Sharon R (författare)
- Middlemore Hospital, Auckland
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- Stoppa, Anne-Marie (författare)
- Institut Paoli-Calmettes
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- Gimsing, Peter (författare)
- Copenhagen University Hospital
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- Hamadani, Mehdi (författare)
- Medical College of Wisconsin
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- Borsaru, Gabriela (författare)
- Colțea Hospital
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- Berg, Deborah (författare)
- Takeda Oncology Inc.
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- Lin, Jianchang (författare)
- Takeda Oncology Inc.
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- Di Bacco, Alessandra (författare)
- Takeda Oncology Inc.
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- van de Velde, Helgi (författare)
- Takeda Oncology Inc.
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- Richardson, Paul G (författare)
- Dana-Farber Cancer Institute
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- Moreau, Philippe (författare)
- Nantes University Hospital
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(creator_code:org_t)
- 2017-07-27
- 2017
- Engelska 9 s.
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Ingår i: Haematologica. - : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 102:10, s. 1767-1775
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Prior treatment exposure in patients with relapsed/refractory multiple myeloma may affect outcomes with subsequent therapies. We analyzed efficacy and safety according to prior treatment in the phase 3 TOURMALINE-MM1 study of ixazomib-lenalidomide-dexamethasone (ixazomib-Rd) versus placebo-Rd. Patients with relapsed/refractory multiple myeloma received ixazomib-Rd or placebo-Rd. Efficacy and safety were evaluated in subgroups defined according to type (proteasome inhibitor [PI] and immunomodulatory drug) and number (1 vs. 2 or 3) of prior therapies received. Of 722 patients, 503 (70%) had received a prior PI, and 397 (55%) prior lenalidomide/thalidomide; 425 patients had received 1 prior therapy, and 297 received 2 or 3 prior therapies. At a median follow up of ~15 months, PFS was prolonged with ixazomib-Rd vs. placebo-Rd regardless of type of prior therapy received; HR 0.739 and 0.749 in PI-exposed and -naïve patients, HR 0.744 and 0.700 in immunomodulatory-drug-exposed and -naïve patients, respectively. PFS benefit with ixazomib-Rd vs. placebo-Rd appeared greater in patients with 2 or 3 prior therapies (HR 0.58) and in those with 1 prior therapy without prior transplant (HR 0.60) versus those with 1 prior therapy and transplant (HR 1.23). Across all subgroups, toxicity was consistent with that seen in the intent-to-treat population. In patients with relapsed/refractory multiple myeloma, ixazomib-Rd was associated with a consistent clinical benefit vs. placebo-Rd regardless of prior treatment with bortezomib or immunomodulatory drugs. Patients with 2 or 3 prior therapies, or 1 prior therapy without transplant seemed to have greater benefit than patients with 1 prior therapy and transplant. TOURMALINE-MM1 registered at clinicaltrials.gov identifier: 01564537.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Journal Article
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mateos, María-Vi ...
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Masszi, Tamas
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Grzasko, Norbert
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Hansson, Markus
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Sandhu, Irwindee ...
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Pour, Ludek
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Viterbo, Luísa
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Jackson, Sharon ...
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Stoppa, Anne-Mar ...
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Gimsing, Peter
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Hamadani, Mehdi
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Borsaru, Gabriel ...
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Berg, Deborah
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Lin, Jianchang
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Di Bacco, Alessa ...
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van de Velde, He ...
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Richardson, Paul ...
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Moreau, Philippe
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Haematologica
- Av lärosätet
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Lunds universitet