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Determinants of hea...
Determinants of health-related quality of life in a multinational systemic sclerosis inception cohort
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- Morrisroe, Kathleen (author)
- St. Vincent's Hospital, Melbourne,University of Melbourne
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- Hudson, Marie (author)
- Jewish General Hospital
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- Baron, Murray (author)
- Jewish General Hospital
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- de Vries-Bouwstra, Jeska (author)
- Leiden University Medical Centre
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- Carreira, Patricia E. (author)
- 12 de Octubre University Hospital
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- Wuttge, Dirk M. (author)
- Lund University,Lunds universitet,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Lund Systemic Sclerosis Research Group,Lund University Research Groups,Skåne University Hospital
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- Wang, Mianbo (author)
- Jewish General Hospital
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- Frech, Tracy M. (author)
- Veterans Health Administration, U.S. Department of Veteran Affairs,University of Utah
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- Stevens, Wendy (author)
- St. Vincent's Hospital, Melbourne
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- Proudman, Susanna M. (author)
- University of Adelaide,Royal Adelaide Hospital
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- Nikpour, Mandana (author)
- St. Vincent's Hospital, Melbourne,University of Melbourne
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St Vincent's Hospital, Melbourne University of Melbourne (creator_code:org_t)
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- 2018
- 2018
- English 8 s.
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In: Clinical and Experimental Rheumatology. - 0392-856X. ; 36:4, s. 53-60
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Abstract
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- OBJECTIVES: To evaluate health-related quality of life (HRQoL) and its determinants in a systemic sclerosis (SSc) multinational inception cohort. We performed a meta-analysis of data from individual countries, and compared the meta-analysis to individual country results by pooling data from each of the countries.METHODS: SSc patients within 2 years of disease onset were recruited from 5 countries participating in the International Systemic Sclerosis Inception Cohort (INSYNC). Data from each country's database were exported for analysis using a harmonised platform. HRQoL was assessed using the Medical Outcomes Short Form-36 (SF-36). Multivariate linear regression assessed associations between HRQoL and predictors in cohorts separately and meta-analyzed to generate pooled estimates. The analyses were repeated using individual patient data.RESULTS: Of the 637 SSc patients recruited, the majority was female (80.2%-83.3%), aged between 52.4-56.7 years with limited cutaneous disease subtype (48.6%-66.7%). HRQoL scores were lower for SSc patients than the general population (SF-36 physical component summary (PCS) score (36.4-39.6), mental component summary (MCS) score (41.0-46.4)). Determinants of SF-36 PCS by meta-analysis included increasing age (β=-0.1, 95%CI -0.2, -0.01), diffuse cutaneous disease subtype (β=-8.4, 95%CI -10.6, -6.3), and pulmonary arterial hypertension (β=-10.9, 95%CI -16.6, -5.3). Increasing age (β=0.09, 95%CI 0.0, 0.18) was the only variable associated with SF-36 MCS. Analyses using individual patient data revealed similar results to those of the meta-analysis of cohort data.CONCLUSIONS: Our study provides estimates of HRQoL in a large inception SSc cohort and provides evidence that individual patient data analysis is valid in the INSYNC dataset.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- art (subject category)
- ref (subject category)
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Morrisroe, Kathl ...
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Hudson, Marie
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Baron, Murray
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de Vries-Bouwstr ...
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Carreira, Patric ...
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Wuttge, Dirk M.
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show more...
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Wang, Mianbo
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Frech, Tracy M.
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Stevens, Wendy
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Proudman, Susann ...
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Nikpour, Mandana
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Clinical and Exp ...
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Lund University