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Suppression of epil...
Suppression of epileptogenesis by modification of N-methyl-D-aspartate receptor subunit composition
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- Bengzon, Johan (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurokirurgi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurosurgery,Section IV,Department of Clinical Sciences, Lund
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- Okabe, Shigeo (författare)
- Lund University
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- Lindvall, Olle (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Mckay, Ronald D. G. (författare)
- National Institutes of Health, United States
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(creator_code:org_t)
- 2001-12-24
- 1999
- Engelska.
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Ingår i: European Journal of Neuroscience. - : Wiley. - 0953-816X. ; 11:3, s. 916-922
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure development in kindling epilepsy were assessed in transgenic mice expressing high neuronal levels of NR2D under control of the calcium/calmodulin kinase II alpha subunit (αCaMKII) promoter. The NR2D subunit is normally present at very low levels in the mature forebrain. Transgenic mice showed a marked reduction of amygdala kindling development. Spread of epileptic activity was retarded acid generalized seizures appeared later in animals overexpressing NR2D compared with wild-type mice. The progressive lengthening of epileptiform activity, which normally occurs in kindling, was also dampened in transgenic animals. We conclude that NMDA receptor subunit composition determines the progression of experimental epilepsy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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