Search: id:"swepub:oai:lup.lub.lu.se:648d9ebf-4709-4ec9-908c-5ce619d2772e" >
Type 2 diabetes exa...
Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness : cross-sectional and longitudinal evidence from the SUMMIT study
-
- Aizawa, Kunihiko (author)
- University of Exeter
-
- Gates, Phillip E. (author)
- University of Exeter
-
- Mawson, David M. (author)
- University of Exeter
-
show more...
-
- Casanova, Francesco (author)
- University of Exeter
-
- Gooding, Kim M. (author)
- University of Exeter
-
- Hope, Suzy V. (author)
- University of Exeter
-
- Goncalves, Isabel (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
-
- Nilsson, Jan (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
-
- Khan, Faisel (author)
- University of Dundee
-
- Colhoun, Helen M. (author)
- University of Edinburgh
-
- Natali, Andrea (author)
- University of Pisa
-
- Palombo, Carlo (author)
- University of Pisa
-
- Shore, Angela C. (author)
- University of Exeter
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English 10 s.
-
In: Journal of Applied Physiology. - 8750-7587. ; 136:1, s. 13-22
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Greater central artery stiffness is observed in people with type 2 diabetes (T2DM). Elevated blood pressure (BP) and altered arterial wall structure/composition in T2DM are generally considered as main drivers for this alteration. However, because conventional arterial stiffness measures are BP-dependent and as such an influence of BP remains in a measure, it is unclear if greater central artery stiffness is a function of greater BP, or due to changes in the structure and composition of the arterial wall. We aimed to measure BP-independent arterial stiffness (b0) cross-sectionally and longitudinally in T2DM. We studied 753 adults with T2DM (DM þ) and 436 adults without (DM-) at baseline (Phase 1), and 310 DM þ and 210 DM- adults at 3-yr follow-up (Phase 2). We measured carotid-femoral pulse wave velocity and used it to calculate b0. In Phase 1, b0 was significantly greater in DM þ than DM- after adjusting for age and sex [27.5 (26.6–28.3) vs. 23.6 (22.4–24.8) au, P < 0.001]. Partial correlation analyses after controlling for age and sex showed that b0 was significantly associated with hemoglobin A1c (r ¼ 0.15 P < 0.001) and heart rate [(HR): r ¼ 0.23 P < 0.001)] in DM þ . In Phase 2, percentage-change in b0 was significantly greater in DM þ than DM-[19.5 (14.9–24.0) vs. 5.0 (-0.6 to 10.6) %, P < 0.001] after adjusting for age, sex, and baseline b0. b0 was greater in DM þ than DM- and increased much more in DM þ than in DM- over 3 yr. This suggests that T2DM exacerbates BP-independent arterial stiffness and may have a complemental utility to existing arterial stiffness indices. NEW & NOTEWORTHY We demonstrate in this study a greater BP-independent arterial stiffness b0 in people with type 2 diabetes (T2DM) compared to those without, and also a greater change in b0 over 3 yr in people with T2DM than those without. These findings suggest that the intrinsic properties of the arterial wall may change in a different and more detrimental way in people with T2DM and likely represents accumulation of cardiovascular risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- aging
- aorta
- blood pressure
- ultrasound
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Aizawa, Kunihiko
-
Gates, Phillip E ...
-
Mawson, David M.
-
Casanova, France ...
-
Gooding, Kim M.
-
Hope, Suzy V.
-
show more...
-
Goncalves, Isabe ...
-
Nilsson, Jan
-
Khan, Faisel
-
Colhoun, Helen M ...
-
Natali, Andrea
-
Palombo, Carlo
-
Shore, Angela C.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Journal of Appli ...
- By the university
-
Lund University