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Long term predictiv...
Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study.
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- Dillner, Joakim (författare)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Rebolj, Matejka (författare)
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Birembaut, Philippe (författare)
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Petry, Karl-Ulrich (författare)
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Szarewski, Anne (författare)
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Munk, Christian (författare)
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de Sanjose, Silvia (författare)
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- Naucler, Pontus (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Lloveras, Belen (författare)
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Kjaer, Susanne (författare)
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Cuzick, Jack (författare)
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van Ballegooijen, Marjolein (författare)
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Clavel, Christine (författare)
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Iftner, Thomas (författare)
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- Wadell, Göran (författare)
- Umeå universitet,Virologi
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(creator_code:org_t)
- BMJ, 2008
- 2008
- Engelska.
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Ingår i: BMJ: British Medical Journal. - : BMJ. - 1756-1833 .- 0959-8138 .- 1468-5833. ; 337
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://www.bmj.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+). DESIGN: Multinational cohort study with joint database analysis. SETTING: Seven primary HPV screening studies in six European countries. PARTICIPANTS: 24,295 women attending cervical screening enrolled into HPV screening trials who had at least one cervical cytology or histopathology examination during follow-up. MAIN OUTCOME MEASURE: Long term cumulative incidence of CIN3+. RESULTS: The cumulative incidence rate of CIN3+ after six years was considerably lower among women negative for HPV at baseline (0.27%, 95% confidence interval 0.12% to 0.45%) than among women with negative results on cytology (0.97%, 0.53% to 1.34%)). By comparison, the cumulative incidence rate for women with negative cytology results at the most commonly recommended screening interval in Europe (three years) was 0.51% (0.23% to 0.77%). The cumulative incidence rate among women with negative cytology results who were positive for HPV increased continuously over time, reaching 10% at six years, whereas the rate among women with positive cytology results who were negative for HPV remained below 3%. CONCLUSIONS: A consistently low six year cumulative incidence rate of CIN3+ among women negative for HPV suggests that cervical screening strategies in which women are screened for HPV every six years are safe and effective.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Uterine Cervical Neoplasms: virology
- Uterine Cervical Neoplasms: epidemiology
- Uterine Cervical Neoplasms: diagnosis
- Papillomavirus Infections: epidemiology
- Papillomavirus Infections: diagnosis
- Europe: epidemiology
- Cervical Intraepithelial Neoplasia: virology
- Cervical Intraepithelial Neoplasia: diagnosis
- Cervical Intraepithelial Neoplasia: epidemiology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Dillner, Joakim
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Rebolj, Matejka
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Birembaut, Phili ...
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Petry, Karl-Ulri ...
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Szarewski, Anne
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Munk, Christian
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visa fler...
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de Sanjose, Silv ...
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Naucler, Pontus
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Lloveras, Belen
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Kjaer, Susanne
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Cuzick, Jack
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van Ballegooijen ...
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Clavel, Christin ...
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Iftner, Thomas
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Wadell, Göran
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
- Artiklar i publikationen
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BMJ: British Med ...
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BMJ
- Av lärosätet
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Lunds universitet
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Umeå universitet
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Karolinska Institutet