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Tract-based white m...
Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach
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- Rumetshofer, Theodor (author)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Inglese, Francesca (author)
- Leiden University Medical Centre
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- de Bresser, Jeroen (author)
- Leiden University Medical Centre
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- Mannfolk, Peter (author)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Strandberg, Olof (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,MR Physics,Clinical Memory Research,Lund University Research Groups
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Bengtsson, Anders (author)
- Lund University,Lunds universitet,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Nilsson, Markus (author)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Multidimensional microstructure imaging,Neuroradiologi,Faculty of Medicine,Lund University Research Groups,Neuroradiology
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- Knutsson, Linda (author)
- Lund University,Lunds universitet,MR Physics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Johns Hopkins University School of Medicine,Kennedy Krieger Institute
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- Lätt, Jimmy (author)
- Skåne University Hospital
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- Steup-Beekman, Gerda M (author)
- Leiden University Medical Centre
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- Huizinga, Tom W J (author)
- Leiden University Medical Centre
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- van Buchem, Mark A (author)
- Leiden University Medical Centre
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- Ronen, Itamar (author)
- University of Brighton
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- Sundgren, Pia C (author)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Faculty of Medicine,Neuroradiology,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2022-12-09
- 2022
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12, s. 1-12
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Abstract
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- Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore the strategic location of WMH. The goal of this work was to develop a fully-automated method to identify predominant patterns of WMH across WM tracts based on cluster analysis. A total of 221 SLE patients with and without neuropsychiatric symptoms from two different sites were included in this study. WMH segmentations and lesion locations were acquired automatically. Cluster analysis was performed on the WMH distribution in 20 WM tracts. Our pipeline identified five distinct clusters with predominant involvement of the forceps major, forceps minor, as well as right and left anterior thalamic radiations and the right inferior fronto-occipital fasciculus. The patterns of the affected WM tracts were consistent over the SLE subtypes and sites. Our approach revealed distinct and robust tract-based WMH patterns within SLE patients. This method could provide a basis, to link the location of WMH with clinical symptoms. Furthermore, it could be used for other diseases characterized by presence of WMH to investigate both the clinical relevance of WMH and underlying pathomechanism in the brain.
Subject headings
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- By the author/editor
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Rumetshofer, The ...
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Inglese, Frances ...
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de Bresser, Jero ...
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Mannfolk, Peter
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Strandberg, Olof
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Jönsen, Andreas
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show more...
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Bengtsson, Ander ...
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Nilsson, Markus
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Knutsson, Linda
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Lätt, Jimmy
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Steup-Beekman, G ...
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Huizinga, Tom W ...
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van Buchem, Mark ...
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Ronen, Itamar
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Sundgren, Pia C
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show less...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Lund University