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DNA methylation ris...
DNA methylation risk score for type 2 diabetes is associated with gestational diabetes
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- Linares-Pineda, Teresa M (author)
- University of Granada
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- Fragoso-Bargas, Nicolas (author)
- Oslo university hospital
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- Picón, María José (author)
- Hospitales Regional Universitario y Virgen de la Victoria de Málaga
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- Molina-Vega, Maria (author)
- Hospitales Regional Universitario y Virgen de la Victoria de Málaga
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- Jenum, Anne Karen (author)
- University of Oslo
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- Sletner, Line (author)
- Akershus University Hospital
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- Lee-Ødegård, Sindre (author)
- University of Oslo
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- Opsahl, Julia O. (author)
- Haukeland University Hospital
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- Moen, Gunn-Helen (author)
- University of Bristol
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- Qvigstad, Elisabeth (author)
- Oslo university hospital
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- Prasad, Rashmi B (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Birkeland, Kåre I (author)
- Oslo university hospital
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- Morcillo, Sonsoles (author)
- Hospitales Regional Universitario y Virgen de la Victoria de Málaga
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- Sommer, Christine (author)
- Oslo university hospital
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Cardiovascular Diabetology. - 1475-2840. ; 23
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Abstract
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- BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n = 32), DNA methylation in peripheral blood leukocytes was measured at a gestational age of 28 ± 2. We constructed an MRS in EPIPREG and EPIDG based on CpG hits from a published epigenome-wide association study (EWAS) of T2DM.RESULTS: With mixed models logistic regression of EPIPREG and EPIDG, MRS for T2DM was associated with GDM: odd ratio (OR)[95% CI]: 1.3 [1.1-1.8], P = 0.002 for the unadjusted model, and 1.4 [1.1-1.7], P = 0.00014 for a model adjusted by age, pre-pregnant BMI, family history of diabetes and smoking status. Also, we found 6 CpGs through a meta-analysis (cg14020176, cg22650271, cg14870271, cg27243685, cg06378491, cg25130381) associated with GDM, and some of their methylation quantitative loci (mQTLs) were related to T2DM and GDM.CONCLUSION: For the first time, we show that DNA methylation marks for T2DM are also associated with GDM, suggesting shared epigenetic mechanisms between GDM and T2DM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Pregnancy
- Female
- Humans
- Diabetes, Gestational/diagnosis
- DNA Methylation
- Diabetes Mellitus, Type 2/diagnosis
- Epigenesis, Genetic
- Risk Factors
Publication and Content Type
- art (subject category)
- ref (subject category)
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Linares-Pineda, ...
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Fragoso-Bargas, ...
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Picón, María Jos ...
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Molina-Vega, Mar ...
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Jenum, Anne Kare ...
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Sletner, Line
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Lee-Ødegård, Sin ...
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Opsahl, Julia O.
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Moen, Gunn-Helen
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Qvigstad, Elisab ...
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Prasad, Rashmi B
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Birkeland, Kåre ...
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Morcillo, Sonsol ...
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Sommer, Christin ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Cardiovascular D ...
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Lund University