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Sertraline in sympt...
Sertraline in symptomatic chronic breathlessness : a double blind, randomised trial
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- Currow, David C. (författare)
- University of Technology Sydney,Flinders University
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- Ekström, Magnus (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Breathlessness and chronic respiratory failure,Lund University Research Groups,University of Technology Sydney
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- Louw, Sandra (författare)
- McCloud Consulting Group
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- Hill, Julie (författare)
- McCloud Consulting Group
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- Fazekas, Belinda (författare)
- University of Technology Sydney,Flinders University
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- Clark, Katherine (författare)
- University of Sydney,University of Technology Sydney
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- Davidson, Patricia M. (författare)
- Johns Hopkins University,University of Technology Sydney
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- McDonald, Christine (författare)
- Austin Health
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- Sajkov, Dimitar (författare)
- Flinders Medical Centre
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- McCaffrey, Nikki (författare)
- Deakin University
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- Doogue, Matthew (författare)
- University of Otago
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- Abernethy, Amy P. (författare)
- Duke University,Flinders University
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- Agar, Meera (författare)
- University of Technology Sydney
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(creator_code:org_t)
- 2018-10-25
- 2019
- Engelska.
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 53:1
- Relaterad länk:
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http://dx.doi.org/10...
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https://erj.ersjourn...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Does sertraline provide symptomatic relief for chronic breathlessness in people with advanced disease whose underlying cause(s) are optimally treated?223 participants with chronic breathlessness (modified Medical Research Council breathlessness scale ≥2) who had optimal treatment of underlying cause(s) were randomised 1:1 to sertraline 25-100 mg (titrated upwards over 9 days) or placebo for 4 weeks. The primary outcome was the proportion who had an improvement in intensity of current breathlessness >15% from baseline on a 100-mm visual analogue scale.The proportion of people responding to sertraline was similar to placebo for current breathlessness on days 26-28 (OR 1.00, 95% CI 0.71-1.40) and for other measures of breathlessness. Quality of life in the sertraline arm had a higher likelihood of improving than in the placebo arm over the 4 weeks (OR 0.21, 95% CI 0.01-0.41; p=0.044). No differences in performance status, anxiety and depression, or survival were observed. Adverse event rates were similar between arms.Sertraline does not appear to provide any benefit over placebo in the symptomatic relief of chronic breathlessness in this patient population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Currow, David C.
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Ekström, Magnus
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Louw, Sandra
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Hill, Julie
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Fazekas, Belinda
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Clark, Katherine
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visa fler...
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Davidson, Patric ...
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McDonald, Christ ...
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Sajkov, Dimitar
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McCaffrey, Nikki
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Doogue, Matthew
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Abernethy, Amy P ...
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Agar, Meera
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
- Artiklar i publikationen
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The European res ...
- Av lärosätet
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Lunds universitet