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Comprehensive lipid...
Comprehensive lipidomics in apoM−/− mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation
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- Shi, Yuanping (författare)
- Third Affiliated Hospital of Soochow University
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- Lam, Sin Man (författare)
- Institute of Genetics and Developmental Biology Chinese Academy of Sciences
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- Liu, Hong (författare)
- Third Affiliated Hospital of Soochow University
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- Luo, Guanghua (författare)
- Third Affiliated Hospital of Soochow University
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- Zhang, Jun (författare)
- Third Affiliated Hospital of Soochow University
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- Yao, Shuang (författare)
- Third Affiliated Hospital of Soochow University
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- Li, Jie (författare)
- Institute of Genetics and Developmental Biology Chinese Academy of Sciences
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- Zheng, Lu (författare)
- Third Affiliated Hospital of Soochow University
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- Xu, Ning (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Zhang, Xiaoying (författare)
- Third Affiliated Hospital of Soochow University
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- Shui, Guanghou (författare)
- Institute of Genetics and Developmental Biology Chinese Academy of Sciences
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 12 s.
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Ingår i: Journal of Genetics and Genomics. - : Elsevier BV. - 1673-8527. ; 47:9, s. 523-534
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Apolipoprotein M (apoM) participates in both high-density lipoprotein and cholesterol metabolism. Little is known about how apoM affects lipid composition of the liver and serum. In this study, we systemically investigated the effects of apoM on liver and plasma lipidomes and how apoM participates in lipid cycling, via apoM knockout in mice and the human SMMC-7721 cell line. We used integrated mass spectrometry–based lipidomics approaches to semiquantify more than 600 lipid species from various lipid classes, which include free fatty acids, glycerolipids, phospholipids, sphingolipids, glycosphingolipids, cholesterol, and cholesteryl esters (CEs), in apoM−/− mouse. Hepatic accumulation of neutral lipids, including CEs, triacylglycerols, and diacylglycerols, was observed in apoM−/− mice; while serum lipidomic analyses showed that, in contrast to the liver, the overall levels of CEs and saturated/monounsaturated fatty acids were markedly diminished. Furthermore, the level of ApoB-100 was dramatically increased in the liver, whereas significant reductions in both ApoB-100 and low-density lipoprotein (LDL) cholesterol were observed in the serum of apoM−/− mice, which indicated attenuated hepatic LDL secretion into the circulation. Lipid profiles and proinflammatory cytokine levels indicated that apoM−/− leads to hepatic steatosis and an overall state of metabolic distress. Taken together, these results revealed that apoM knockout leads to hepatic steatosis, impaired lipid secretion, and an overall state of metabolic distress.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
Nyckelord
- Apolipoprotein M
- Lipid metabolism
- Lipidomics
- Lipoprotein
- Nonalcoholic fatty liver disease
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Shi, Yuanping
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Lam, Sin Man
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Liu, Hong
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Luo, Guanghua
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Zhang, Jun
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Yao, Shuang
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visa fler...
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Li, Jie
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Zheng, Lu
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Xu, Ning
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Zhang, Xiaoying
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Shui, Guanghou
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Läkemedelskemi
- Artiklar i publikationen
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Journal of Genet ...
- Av lärosätet
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Lunds universitet