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Characterisation of...
Characterisation of Fasting and Postprandial NMR Metabolites : Insights from the ZOE PREDICT 1 Study
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- Bermingham, Kate M. (författare)
- King's College London
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- Mazidi, Mohsen (författare)
- University of Oxford,King's College London
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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- Maher, Tyler (författare)
- King's College London
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- Valdes, Ana M. (författare)
- University of Nottingham
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- Linenberg, Inbar (författare)
- King's College London
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Wolf, Jonathan (författare)
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Hadjigeorgiou, George (författare)
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- Spector, Tim D. (författare)
- King's College London
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- Menni, Cristina (författare)
- King's College London
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- Ordovas, Jose M. (författare)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Jean Mayer USDA Human Nutrition Research Center on Aging,Madrid Institute For Advanced Studies (IMDEA) Food Institute
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- Berry, Sarah E. (författare)
- King's College London
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- Hall, Wendy L. (författare)
- King's College London
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Nutrients. - 2072-6643. ; 15:11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly lipids, were measured by a Nightingale NMR panel in fasting and postprandial (4 and 6 h after a 3.7 MJ mixed nutrient meal, with a second 2.2 MJ mixed nutrient meal at 4 h) serum samples. For each metabolite, inter- and intra-individual variability over time was evaluated using linear mixed modelling and intraclass correlation coefficients (ICC) were calculated. Results: Postprandially, 85% (of 250 metabolites) significantly changed from fasting at 6 h (47% increased, 53% decreased; Kruskal–Wallis), with 37 measures increasing by >25% and 14 increasing by >50%. The largest changes were observed in very large lipoprotein particles and ketone bodies. Seventy-one percent of circulating metabolites were strongly correlated (Spearman’s rho >0.80) between fasting and postprandial timepoints, and 5% were weakly correlated (rho <0.50). The median ICC of the 250 metabolites was 0.91 (range 0.08–0.99). The lowest ICCs (ICC <0.40, 4% of measures) were found for glucose, pyruvate, ketone bodies (β-hydroxybutyrate, acetoacetate, acetate) and lactate. Conclusions: In this large-scale postprandial metabolomic study, circulating metabolites were highly variable between individuals following sequential mixed meals. Findings suggest that a meal challenge may yield postprandial responses divergent from fasting measures, specifically for glycolysis, essential amino acid, ketone body and lipoprotein size metabolites.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- lipids
- lipoproteins
- nuclear magnetic resonance (NMR)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bermingham, Kate ...
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Mazidi, Mohsen
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Franks, Paul W.
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Maher, Tyler
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Valdes, Ana M.
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Linenberg, Inbar
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visa fler...
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Wolf, Jonathan
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Hadjigeorgiou, G ...
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Spector, Tim D.
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Menni, Cristina
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Ordovas, Jose M.
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Berry, Sarah E.
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Hall, Wendy L.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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Nutrients
- Av lärosätet
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Lunds universitet