Search: id:"swepub:oai:lup.lub.lu.se:75c6c31d-c232-432f-bcc2-033e4d009824" >
Evaluation of Plate...
Evaluation of Platelet Responses in Transfusion-Related Acute Lung Injury (TRALI)
-
- Zeeuw van der Laan, Eveline A.N. (author)
- Academic Medical Center of University of Amsterdam (AMC)
-
- van der Velden, Saskia (author)
- Academic Medical Center of University of Amsterdam (AMC)
-
- Porcelijn, Leendert (author)
- Sanquin Diagnostic Services
-
show more...
-
- Semple, John W. (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
-
- van der Schoot, C. Ellen (author)
- Academic Medical Center of University of Amsterdam (AMC)
-
- Kapur, Rick (author)
- Academic Medical Center of University of Amsterdam (AMC)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English 7 s.
-
In: Transfusion Medicine Reviews. - : Elsevier BV. - 0887-7963. ; 34:4, s. 227-233
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Platelets are versatile cells which are capable of eliciting nonhemostatic immune functions, especially under inflammatory conditions. Depending on the specific setting, platelets may be either protective or pathogenic in acute lung injury and acute respiratory distress syndrome (ARDS). Their role in transfusion-related acute lung injury (TRALI) is less well defined; however, it has been hypothesized that recipient platelets and transfused platelets both play a pathogenic role in TRALI. Overall, despite conflicting findings, it appears that recipient platelets may play a pathogenic role in antibody-mediated TRALI; however, their contribution appears to be limited. It is imperative to first validate the involvement of recipient platelets by standardizing the animal models, methods, reagents, and readouts for lung injury and taking the animal housing environment into consideration. For the involvement of transfused platelets in TRALI, it appears that predominantly lipids such as ceramide in stored platelets are able to induce TRALI in animal models. These studies will also need to be validated, and moreover, the platelet-derived lipid-mediated mechanisms leading to TRALI will need to be investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- 34-1-2S
- Ceramide
- Lipids
- Platelets
- TRALI
- Transfusion-related acute lung injury
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
To the university's database