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Waning protection a...
Waning protection after vaccination and prior infection against COVID-19-related mortality over 18 months
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- Dietler, Dominik (author)
- Lund University,Lunds universitet,EPI@LUND,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Kahn, Fredrik (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neutrofiler – nya mekanismer och nya markörer,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Neutrophils – new mechanisms and new biomarkers,Lund University Research Groups,Skåne University Hospital
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- Inghammar, Malin (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Björk, Jonas (author)
- Lund University,Lunds universitet,Kirurgi och folkhälsa,Forskargrupper vid Lunds universitet,EPI@LUND,Surgery and public health,Lund University Research Groups
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Clinical Microbiology and Infection. - 1469-0691. ; 29:12, s. 1573-1580
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Abstract
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- OBJECTIVES: Evidence on waning patterns in protection from vaccine-induced, infection-induced, and hybrid immunity against death is scarce. The aim of this study is to assess the temporal trends in protection against mortality.METHODS: Population-based case-control study nested in the total population of Scania Region, Sweden using individual-level registry data of COVID-19-related deaths (<30 days after positive SARS-CoV-2 test) between 27 December 2020 and 3 June 2022. Controls were matched for age, sex, and index date. Conditional logistic regression was used to estimate the preventable fraction (PF) from vaccination (PF vac corresponding to vaccine effectiveness; ≥2 vaccine doses vs. 0 doses), prior infection (PF inf), and hybrid immunity (PF hybrid). PF was calculated as one minus odds ratio. Models were adjusted for comorbidities, long-term care facility residence, prior infection (for PF vac), country of birth, socio-economic conditions, and time since last vaccination (for PF inf). RESULTS: In total, 14 936 individuals (1440 COVID-19-related deaths and 13 496 controls) were included in the case-control analyses (45% females, median age: 84 years). PF vac was above 90% during the first month after vaccination, regardless of the number of vaccine doses. After 6 months, PF vac of two doses waned to 34% (95% CI: -30% to 66%). PF inf for people surviving a SARS-CoV-2 infection waned from 88% (-16% to 99%) 3 months after infection to 62% (34-79%) after 9 months. No differences in waning patterns in PF vac were seen between virus variants, gender, and age. DISCUSSION: Given the waning of protection against death, continuous surveillance of population immunity status, particularly among the most vulnerable population groups, could help to further fine-tune vaccination recommendations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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