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Molecular imaging w...
Molecular imaging with endogenous substances
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- Golman, Klaes (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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Ardenaer-Larsen, JH (författare)
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Petersson, JS (författare)
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- Månsson, Sven (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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Leunbach, I (författare)
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(creator_code:org_t)
- 2003-08-20
- 2003
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences. - : Proceedings of the National Academy of Sciences. - 1091-6490 .- 0027-8424. ; 100:18, s. 10435-10439
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.pnas.org/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Dynamic nuclear polarization has enabled hyperpolarization of nuclei such as C-13 and N-15 in endogenous substances. The resulting high nuclear polarization makes it possible to perform subsecond C-13 MRI. By using the dynamic nuclear polarization hyperpolarization technique, 10% polarization was obtained in an aqueous solution of 100 mM C-13-labeled urea, ready for injection. The in vivo T, relaxation time of C-13 in the urea solution was determined to 20 +/- 2 s. Due to the long relaxation time, it is possible to use the hyperpolarized substance for medical imaging. A series of high-resolution (approximate to1-mm) magnetic resonance images were acquired, each with a scan time of 240 ms, 0-5 s after an i.v. injection of the hyperpolarized aqueous [C-13]urea solution in a rat. The results show that it is possible to perform C-13 angiography with a signal-to-noise ratio of approximate to275 in approximate to0.25 s. Perfusion studies with endogenous substances may allow higher spatial and/or temporal resolution than is possible with current proton imaging techniques.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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