Sökning: id:"swepub:oai:lup.lub.lu.se:787e1b2a-1ce1-4568-954c-3f018cc3fdfe" >
Increase in neuroge...
Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats
-
- Marcussen, A B (författare)
- H. Lundbeck A/S, Denmark;University of Copenhagen, Denmark
-
- Flagstad, P (författare)
- H. Lundbeck A/S, Denmark
-
- Kristjansen, P E G (författare)
- University of Copenhagen, Denmark
-
visa fler...
-
- Johansen, F F (författare)
- University of Copenhagen, Denmark
-
- Englund Johansson, Ulrica (författare)
- Lund University,Lunds universitet,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,H. Lundbeck A/S, Denmark;Lund University Hospital, Lund
-
visa färre...
-
H Lundbeck A/S, Denmark;University of Copenhagen, Denmark H. Lundbeck A/S, Denmark (creator_code:org_t)
- 2007-08-31
- 2008
- Engelska.
-
Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 1600-0404 .- 0001-6314. ; 117:2, s. 94-100
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective - Disturbances in hippocampal neurogenesis may be involved in the pathophysiology of depression and it has been argued that an increase in the generation of new nerve cells in the hippocampus is involved in the mechanism of action of antidepressants. Materials and Methods - Adult Wistar rats were treated with fluoxetine (10 mg/kg) 1 h, daily for 5 (subchronic) or 28 days (chronic) before the Novelty Suppressed Feeding test was performed. Cell proliferation and neurogenesis were analysed using the markers 5-bromo-deoxy-2'-uridine, Ki-67, and doublecortin. Results - A significant behavioural effect was found after 28 days of fluoxetine administration. However, no behavioural improvement was demonstrated after acute and subchronic treatment with fluoxetine. We further demonstrate that chronic antidepressant treatment increases cell proliferation as well as neurogenesis in the dentate gyrus, here using Wistar rats. Conclusions - In further development of antidepressants, neurogenesis may serve as an important parameter to examine the efficacy and mechanism of action of novel drugs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- hippocampus
- behaviour
- antidepressants
- cell proliferation
- neurogenesis
- Biomedical Sciences
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas