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Transcription factor-based direct conversion of human fibroblasts to functional astrocytes
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- Quist, Ella (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups
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- Trovato, Francesco (författare)
- Lund University,Lunds universitet,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups,Skåne University Hospital
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- Avaliani, Natalia (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Zetterdahl, Oskar G. (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Glia och nervcellsbiologi,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups,Glial and Neuronal Biology
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- Gonzalez-Ramos, Ana (författare)
- Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Cellulär Neurofysiologi och Epilepsi,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Epilepsy Group,Lund University Research Groups,Cellular Neurophysiology and Epilepsy group,Skåne University Hospital
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- Hansen, Marita G. (författare)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Kokaia, Merab (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurologi, Lund,Institutionen för kliniska vetenskaper, Lund,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Neurology, Lund,Department of Clinical Sciences, Lund,Experimental Epilepsy Group,Lund University Research Groups,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,Skåne University Hospital
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- Canals, Isaac (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Glia och nervcellsbiologi,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups,Glial and Neuronal Biology
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- Ahlenius, Henrik (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stamceller, åldrande och neurodegeneration,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Stem Cells, Aging and Neurodegeneration,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska 16 s.
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Ingår i: Stem Cell Reports. - : Elsevier BV. - 2213-6711. ; 17:7, s. 1620-1635
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Astrocytes are emerging key players in neurological disorders. However, their role in disease etiology is poorly understood owing to inaccessibility of primary human astrocytes. Pluripotent stem cell-derived cells fail to mimic age and due to their clonal origin do not mimic genetic heterogeneity of patients. In contrast, direct conversion constitutes an attractive approach to generate human astrocytes that capture age and genetic diversity. We describe efficient direct conversion of human fibroblasts to functional induced astrocytes (iAs). Expression of the minimal combination Sox9 and Nfib generates iAs with molecular, phenotypic, and functional properties resembling primary human astrocytes. iAs could be obtained by conversion of fibroblasts covering the entire human lifespan. Importantly, iAs supported function of induced neurons obtained through direct conversion from the same fibroblast population. Fibroblast-derived iAs will become a useful tool to elucidate the biology of astrocytes and complement current in vitro models for studies of late-onset neurological disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- astrocytes
- direct conversion
- fibroblasts
- neurodegenerative diseases
- neurons
- Nfia
- Nfib
- Sox9
- transcription factors
- transdifferentiation
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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