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Klebsiella pneumoni...
Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis.
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- Guerra, Maria Eduarda Souza (författare)
- University Of São Francisco
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- Destro, Giulia (författare)
- University Of São Francisco
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- Vieira, Brenda (författare)
- University Of São Francisco
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- Lima, Alice S (författare)
- University Of São Francisco
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- Ferraz, Lucio Fabio Caldas (författare)
- University Of São Francisco
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- Hakansson, Anders P (författare)
- Lund University,Lunds universitet,Experimentell infektionsmedicin, Malmö,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Experimental Infection Medicine, Malmö,Lund University Research Groups
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- Darrieux, Michelle (författare)
- University Of São Francisco
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- Converso, Thiago Rojas (författare)
- University Of São Francisco
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(creator_code:org_t)
- 2022-05-11
- 2022
- Engelska.
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Ingår i: Frontiers in cellular and infection microbiology. - : Frontiers Media SA. - 2235-2988. ; 12, s. 1-13
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- The ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae - a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. We also explore different model systems designed to study biofilm formation in this species. A great number of factors contribute to biofilm establishment and maintenance in K. pneumoniae, which highlights the importance of this mechanism for the bacterial fitness. Some of these molecules could be used in future vaccines against this bacterium. However, there is still a lack of in vivo models to evaluate the contribution of biofilm development to disease pathogenesis. With that in mind, the combination of different methodologies has great potential to provide a more detailed scenario that more accurately reflects the steps and progression of natural infection.
Ämnesord
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- Anti-Bacterial Agents/pharmacology
- Bacterial Infections
- Biofilms
- Humans
- Klebsiella pneumoniae/genetics
- Virulence
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
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