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Hematopoietic age a...
Hematopoietic age at onset of triple-negative breast cancer dictates disease aggressiveness and progression
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- Marsh, Timothy (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Wong, Irene (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Sceneay, Jaclyn (författare)
- Harvard University
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- Barakat, Amey (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Qin, Yuanbo (författare)
- Harvard University
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- Sjodin, Andreas (författare)
- Harvard University
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- Alspach, Elise (författare)
- Washington University in St. Louis
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- Nilsson, Björn (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Harvard University
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- Stewart, Sheila A. (författare)
- Washington University in St. Louis
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- Mcallister, Sandra S. (författare)
- Harvard University
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(creator_code:org_t)
- 2016
- 2016
- Engelska 12 s.
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Ingår i: Cancer Research. - 0008-5472. ; 76:10, s. 2932-2943
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Triple-negative breast cancer (TNBC) is considered an early onset subtype of breast cancer that carries with it a poorer prognosis in young rather than older women for reasons that remain poorly understood. Hematopoiesis in the bone marrow becomes altered with age and may therefore affect the composition of tumor-infiltrating hematopoietic cells and subsequent tumor progression. In this study, we investigated how age- and tumor-dependent changes to bone marrow-derived hematopoietic cells impact TNBC progression. Using multiple mouse models of TNBC tumorigenesis and metastasis, we found that a specific population of bone marrow cells (BMC) upregulated CSF-1R and secreted the growth factor granulin to support stromal activation and robust tumor growth in young mice. However, the same cell population in old mice expressed low levels of CSF1R and granulin and failed to promote tumor outgrowth, suggesting that age influences the tumorigenic capacity of BMCs in response to tumor-associated signals. Importantly, BMCs from young mice were sufficient to activate a tumor-supportive microenvironment and induce tumor progression in old mice. These results indicate that hematopoietic age is an important determinant of TNBC aggressiveness and provide rationale for investigating age-stratified therapies designed to prevent the protumorigenic effects of activated BMCs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Marsh, Timothy
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Wong, Irene
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Sceneay, Jaclyn
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Barakat, Amey
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Qin, Yuanbo
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Sjodin, Andreas
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visa fler...
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Alspach, Elise
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Nilsson, Björn
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Stewart, Sheila ...
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Mcallister, Sand ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer Research
- Av lärosätet
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Lunds universitet