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Host-pathogen adhes...
Host-pathogen adhesion as the basis of innovative diagnostics for emerging pathogens
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- van Belkum, Alex (författare)
- bioMérieux SA
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- Almeida, Carina (författare)
- Biomode, S.A.
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- Bardiaux, Benjamin (författare)
- Pasteur Institute
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visa fler...
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- Barrass, Sarah V. (författare)
- University of Helsinki
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- Butcher, Sarah J. (författare)
- University of Helsinki
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- Çaykara, Tuğçe (författare)
- Centre for Nanotechnology and Smart Materials
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- Chowdhury, Sounak (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Datar, Rucha (författare)
- bioMérieux SA
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- Eastwood, Ian (författare)
- Eluceda
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- Goldman, Adrian (författare)
- University of Leeds,University of Helsinki
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- Goyal, Manisha (författare)
- bioMérieux SA
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- Happonen, Lotta (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär patogenes,Forskargrupper vid Lunds universitet,BioMS,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Pathogenesis,Lund University Research Groups
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- Izadi-Pruneyre, Nadia (författare)
- Pasteur Institute
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- Jacobsen, Theis (författare)
- Pasteur Institute
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- Johnson, Pirjo H. (författare)
- University of Leeds
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- Kempf, Volkhard A.J. (författare)
- University Hospital Frankfurt
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- Kiessling, Andreas (författare)
- University of Leeds
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- Bueno, Juan Leva (författare)
- University of Leeds
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- Malik, Anchal (författare)
- University of Leeds
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- Malmström, Johan (författare)
- Lund University,Lunds universitet,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,epIgG,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,BioMS,Lund University Research Groups,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Meuskens, Ina (författare)
- University of Oslo
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- Milner, Paul A. (författare)
- University of Leeds
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- Nilges, Michael (författare)
- Pasteur Institute
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- Pamme, Nicole (författare)
- University of Hull
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- Peyman, Sally A. (författare)
- University of Leeds
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- Rodrigues, Ligia R. (författare)
- University of Minho
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- Rodriguez-Mateos, Pablo (författare)
- University of Hull
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- Sande, Maria G. (författare)
- University of Minho
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- Silva, Carla Joana (författare)
- Centre for Nanotechnology and Smart Materials
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- Stasiak, Aleksandra Cecylia (författare)
- University of Tübingen
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- Stehle, Thilo (författare)
- University of Tübingen
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- Thibau, Arno (författare)
- University Hospital Frankfurt
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- Vaca, Diana J. (författare)
- University Hospital Frankfurt
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- Linke, Dirk (författare)
- University of Oslo
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bioMérieux SA Biomode, SA. (creator_code:org_t)
- 2021-07-14
- 2021
- Engelska.
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Ingår i: Diagnostics. - : MDPI AG. - 2075-4418. ; 11:7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases re-quires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro diagnostic (IVD) tests. Basic science and translational research are needed to identify key microbial molecules as diagnostic targets, to identify relevant host counterparts, and to use this knowledge in developing or improving IVD. In this regard, an overlooked feature is the capacity of pathogens to adhere specifically to host cells and tissues. The molecular entities relevant for pathogen–surface interaction are the so-called adhesins. Adhesins vary from protein compounds to (poly-)saccharides or lipid structures that interact with eukaryotic host cell matrix molecules and receptors. Such interactions co-define the specificity and sensitivity of a diagnostic test. Currently, adhesin-receptor binding is typically used in the pre-analytical phase of IVD tests, focusing on pathogen enrichment. Further exploration of adhesin–ligand interaction, supported by present high-throughput “omics” technolo-gies, might stimulate a new generation of broadly applicable pathogen detection and characterization tools. This review describes recent results of novel structure-defining technologies allowing for detailed molecular analysis of adhesins, their receptors and complexes. Since the host ligands evolve slowly, the corresponding adhesin interaction is under selective pressure to maintain a constant receptor binding domain. IVD should exploit such conserved binding sites and, in particular, use the human ligand to enrich the pathogen. We provide an inventory of methods based on adhesion factors and pathogen attachment mechanisms, which can also be of relevance to currently emerging pathogens, including SARS-CoV-2, the causative agent of COVID-19.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Adhesin
- Diagnostics
- Infectious diseases
- Receptor
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- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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van Belkum, Alex
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Almeida, Carina
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Bardiaux, Benjam ...
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Barrass, Sarah V ...
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Butcher, Sarah J ...
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Çaykara, Tuğçe
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visa fler...
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Chowdhury, Souna ...
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Datar, Rucha
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Eastwood, Ian
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Goldman, Adrian
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Goyal, Manisha
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Happonen, Lotta
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Izadi-Pruneyre, ...
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Jacobsen, Theis
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Johnson, Pirjo H ...
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Kempf, Volkhard ...
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Kiessling, Andre ...
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Bueno, Juan Leva
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Malik, Anchal
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Malmström, Johan
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Meuskens, Ina
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Milner, Paul A.
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Nilges, Michael
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Pamme, Nicole
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Peyman, Sally A.
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Rodrigues, Ligia ...
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Rodriguez-Mateos ...
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Sande, Maria G.
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Silva, Carla Joa ...
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Stasiak, Aleksan ...
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Stehle, Thilo
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Thibau, Arno
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Vaca, Diana J.
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Linke, Dirk
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
- Artiklar i publikationen
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Diagnostics
- Av lärosätet
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Lunds universitet