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Activin A inhibits ...
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.
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Olsen, Oddrun Elise (författare)
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Wader, Karin Fahl (författare)
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Hella, Hanne (författare)
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Mylin, Anne Kærsgaard (författare)
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- Turesson, Ingemar (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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Nesthus, Ingerid (författare)
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Waage, Anders (författare)
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Sundan, Anders (författare)
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Holien, Toril (författare)
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(creator_code:org_t)
- 2015-06-06
- 2015
- Engelska.
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Ingår i: Cell Communication and Signaling. - : Springer Science and Business Media LLC. - 1478-811X. ; 13:1
- Relaterad länk:
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https://portal.resea... (primary) (free)
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http://www.ncbi.nlm.... (free)
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http://dx.doi.org/10... (free)
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https://biosignaling...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in pathological conditions such as cachexia, osteoporosis and cancer. Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3. Activin A has a strong affinity to type 2 receptors, a feature that they share with some of the bone morphogenetic proteins (BMPs). Activin A is also elevated in myeloma patients with advanced disease and is involved in myeloma bone disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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