Sökning: id:"swepub:oai:lup.lub.lu.se:8537a016-e6d0-4fb4-a182-01e20ab87390" >
Birthweight is asso...
Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes
-
- Hansen, Aleksander L. (författare)
- Aarhus University Hospital,Steno Diabetes Center Copenhagen
-
- Thomsen, Reimar W. (författare)
- Aarhus University Hospital
-
- Brøns, Charlotte (författare)
- Steno Diabetes Center Copenhagen
-
visa fler...
-
- Svane, Helene M.L. (författare)
- Aarhus University Hospital
-
- Jensen, Rasmus T. (författare)
- University of Copenhagen
-
- Andersen, Mette K. (författare)
- University of Copenhagen
-
- Hansen, Torben (författare)
- University of Copenhagen
-
- Nielsen, Jens S. (författare)
- Odense University Hospital
-
- Vestergaard, Peter (författare)
- Aalborg University Hospital
-
- Højlund, Kurt (författare)
- Odense University Hospital
-
- Jessen, Niels (författare)
- Steno Diabetes Center Copenhagen
-
- Olsen, Michael H. (författare)
- Holbæk Hospital,University of Southern Denmark
-
- Sørensen, Henrik T. (författare)
- Aarhus University Hospital
-
- Vaag, Allan A. (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Steno Diabetes Center Copenhagen
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska 13 s.
-
Ingår i: Diabetologia. - 0012-186X. ; 66:9, s. 1680-1692
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. Methods: Midwife records were traced for 6866 individuals with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Using a cross-sectional design, we assessed age at diagnosis, anthropomorphic measures, comorbidities, medications, metabolic variables and family history of type 2 diabetes in individuals with the lowest 25% of birthweight (<3000 g) and highest 25% of birthweight (>3700 g), compared with a birthweight of 3000–3700 g as reference, using log-binomial and Poisson regression. Continuous relationships across the entire birthweight spectrum were assessed with linear and restricted cubic spline regression. Weighted polygenic scores (PS) for type 2 diabetes and birthweight were calculated to assess the impact of genetic predispositions. Results: Each 1000 g decrease in birthweight was associated with a 3.3 year (95% CI 2.9, 3.8) younger age of diabetes onset, 1.5 kg/m2 (95% CI 1.2, 1.7) lower BMI and 3.9 cm (95% CI 3.3, 4.5) smaller waist circumference. Compared with the reference birthweight, a birthweight of <3000 g was associated with more overall comorbidity (prevalence ratio [PR] for Charlson Comorbidity Index Score ≥3 was 1.36 [95% CI 1.07, 1.73]), having a systolic BP ≥155 mmHg (PR 1.26 [95% CI 0.99, 1.59]), lower prevalence of diabetes-associated neurological disease, less likelihood of family history of type 2 diabetes, use of three or more glucose-lowering drugs (PR 1.33 [95% CI 1.06, 1.65]) and use of three or more antihypertensive drugs (PR 1.09 [95% CI 0.99, 1.20]). Clinically defined low birthweight (<2500 g) yielded stronger associations. Most associations between birthweight and clinical characteristics appeared linear, and a higher birthweight was associated with characteristics mirroring lower birthweight in opposite directions. Results were robust to adjustments for PS representing weighted genetic predisposition for type 2 diabetes and birthweight. Conclusion/interpretation: Despite younger age at diagnosis, and fewer individuals with obesity and family history of type 2 diabetes, a birthweight <3000 g was associated with more comorbidities, including a higher systolic BP, as well as with greater use of glucose-lowering and antihypertensive medications, in individuals with recently diagnosed type 2 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Age at diagnosis
- Birthweight
- Epidemiology
- Fetal programming
- Polygenic risk score
- Type 2 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hansen, Aleksand ...
-
Thomsen, Reimar ...
-
Brøns, Charlotte
-
Svane, Helene M. ...
-
Jensen, Rasmus T ...
-
Andersen, Mette ...
-
visa fler...
-
Hansen, Torben
-
Nielsen, Jens S.
-
Vestergaard, Pet ...
-
Højlund, Kurt
-
Jessen, Niels
-
Olsen, Michael H ...
-
Sørensen, Henrik ...
-
Vaag, Allan A.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetologia
- Av lärosätet
-
Lunds universitet