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Automatic Gleason g...
Automatic Gleason grading of H&E stained microscopic prostate images using deep convolutional neural networks
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Gummeson, Anna (författare)
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- Arvidsson, Ida (författare)
- Lund University,Lunds universitet,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Ohlsson, Mattias (författare)
- Lund University,Lunds universitet,Beräkningsbiologi och biologisk fysik - Har omorganiserats,Institutionen för astronomi och teoretisk fysik - Har omorganiserats,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Has been reorganised,Department of Astronomy and Theoretical Physics - Has been reorganised,Faculty of Science
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- Overgaard, Niels C. (författare)
- Lund University,Lunds universitet,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Krzyzanowska, Agnieszka (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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- Heyden, Anders (författare)
- Lund University,Lunds universitet,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH
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- Bjartell, Anders (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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- Aström, Kalle (författare)
- Lund University,Lunds universitet,Matematikcentrum,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Mathematical Sciences,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- SPIE, 2017
- 2017
- Engelska.
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Ingår i: Medical Imaging 2017: Digital Pathology. - : SPIE. - 9781510607255 ; 10140
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Prostate cancer is the most diagnosed cancer in men. The diagnosis is confirmed by pathologists based on ocular inspection of prostate biopsies in order to classify them according to Gleason score. The main goal of this paper is to automate the classification using convolutional neural networks (CNNs). The introduction of CNNs has broadened the field of pattern recognition. It replaces the classical way of designing and extracting hand-made features used for classification with the substantially different strategy of letting the computer itself decide which features are of importance. For automated prostate cancer classification into the classes: Benign, Gleason grade 3, 4 and 5 we propose a CNN with small convolutional filters that has been trained from scratch using stochastic gradient descent with momentum. The input consists of microscopic images of haematoxylin and eosin stained tissue, the output is a coarse segmentation into regions of the four different classes. The dataset used consists of 213 images, each considered to be of one class only. Using four-fold cross-validation we obtained an error rate of 7.3%, which is significantly better than previous state of the art using the same dataset. Although the dataset was rather small, good results were obtained. From this we conclude that CNN is a promising method for this problem. Future work includes obtaining a larger dataset, which potentially could diminish the error margin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Annan data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Other Computer and Information Science (hsv//eng)
Nyckelord
- Classification
- Convolutional neural networks
- Deep learning
- Gleason grading
- Prostate cancer
Publikations- och innehållstyp
- kon (ämneskategori)
- ref (ämneskategori)
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