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Clinical diversity ...
Clinical diversity and treatment results in tegumentary leishmaniasis : A European clinical report in 459 patients
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- Guery, Romain (författare)
- Necker-Enfants Malades Hospital
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- Walker, Stephen L. (författare)
- London School of Hygiene and Tropical Medicine
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- Harms, Gundel (författare)
- Berlin Institute of Health (BIH)
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- Neumayr, Andreas (författare)
- University of Basel,Swiss Tropical and Public Health Institute (Swiss TPH),James Cook University
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- Van Thiel, Pieter (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Gangneux, Jean Pierre (författare)
- Rennes University Hospital
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- Clerinx, Jan (författare)
- Institute of Tropical Medicine Antwerp
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- Söbirk, Sara Karlsson (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infektion och immunmodulering,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Infection and immunomodulation,Lund University Research Groups
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- Visser, Leo (författare)
- Leiden University Medical Centre
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- Lachaud, Laurence (författare)
- University of Montpellier
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- Bailey, Mark (författare)
- Birmingham Heartlands Hospital
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- Bart, Aldert (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Ravel, Christophe (författare)
- University of Montpellier
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- Van der Auwera, Gert (författare)
- Institute of Tropical Medicine Antwerp
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- Blum, Johannes (författare)
- James Cook University,University of Basel
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- Lockwood, Diana N. (författare)
- London School of Hygiene and Tropical Medicine
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- Buffet, Pierre (författare)
- Paris Diderot University
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(creator_code:org_t)
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- 2021-10-13
- 2021
- Engelska.
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Ingår i: PLoS Neglected Tropical Diseases. - : Public Library of Science (PLoS). - 1935-2727 .- 1935-2735. ; 15:10
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background Cutaneous leishmaniasis (CL) is frequent in travellers and can involve oro-nasal mucosae. Clinical presentation impacts therapeutic management. Methodology Demographic and clinical data from 459 travellers infected in 47 different countries were collected by members of the European LeishMan consortium. The infecting Leishmania species was identified in 198 patients. Principal findings Compared to Old World CL, New World CL was more frequently ulcerative (75% vs 47%), larger (3 vs 2cm), less frequently facial (17% vs 38%) and less frequently associated with mucosal involvement (2.7% vs 5.3%). Patients with mucosal lesions were older (58 vs 30 years) and more frequently immunocompromised (37% vs 3.5%) compared to patients with only skin lesions. Young adults infected in Latin America with L. braziliensis or L. guyanensis complex typically had an ulcer of the lower limbs with mucosal involvement in 5.8% of cases. Typically, infections with L. major and L. tropica acquired in Africa or the Middle East were not associated with mucosal lesions, while infections with L. infantum, acquired in Southern Europe resulted in slowly evolving facial lesions with mucosal involvement in 22% of cases. Local or systemic treatments were used in patients with different clinical presentations but resulted in similarly high cure rates (89% vs 86%). Conclusion/Significance CL acquired in L. infantum-endemic European and Mediterranean areas displays unexpected high rates of mucosal involvement comparable to those of CL acquired in Latin America, especially in immunocompromised patients. When used as per recommendations, local therapy is associated with high cure rates.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Guery, Romain
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Walker, Stephen ...
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Harms, Gundel
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Neumayr, Andreas
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Van Thiel, Piete ...
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Gangneux, Jean P ...
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visa fler...
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Clerinx, Jan
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Söbirk, Sara Kar ...
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Visser, Leo
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Lachaud, Laurenc ...
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Bailey, Mark
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Bart, Aldert
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Ravel, Christoph ...
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Van der Auwera, ...
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Blum, Johannes
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Lockwood, Diana ...
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Buffet, Pierre
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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PLoS Neglected T ...
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Lunds universitet