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Host and pathogen h...
Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation.
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- Secundino, Ismael (författare)
- University of California System
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- Lizcano, Anel (författare)
- University of California System
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- Roupé, Markus (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Wang, Xiaoxia (författare)
- University of California System
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- Cole, Jason N (författare)
- University of California System
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- Olson, Joshua (författare)
- University of California System
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- Ali, S Raza (författare)
- University of California System
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- Dahesh, Samira (författare)
- University of California System
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- Amayreh, Lenah K (författare)
- University of California System
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Henningham, Anna (författare)
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- Varki, Ajit (författare)
- University of California System
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- Nizet, Victor (författare)
- University of California System
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(creator_code:org_t)
- 2015-09-28
- 2016
- Engelska 233 s.
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Ingår i: Journal of Molecular Medicine. - : Springer Science and Business Media LLC. - 1432-1440 .- 0946-2716. ; 94, s. 219-219
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Inhibitory CD33-related Siglec receptors regulate immune cell activation upon engaging ubiquitous sialic acids (Sias) on host cell surface glycans. Through molecular mimicry, Sia-expressing pathogen group B Streptococcus binds inhibitory human Siglec-9 (hSiglec-9) to blunt neutrophil activation and promote bacterial survival. We unexpectedly discovered that hSiglec-9 also specifically binds high molecular weight hyaluronan (HMW-HA), another ubiquitous host glycan, through a region of its terminal Ig-like V-set domain distinct from the Sia-binding site. HMW-HA recognition by hSiglec-9 limited neutrophil extracellular trap (NET) formation, oxidative burst, and apoptosis, defining HMW-HA as a regulator of neutrophil activation. However, the pathogen group A Streptococcus (GAS) expresses a HMW-HA capsule that engages hSiglec-9, blocking NET formation and oxidative burst, thereby promoting bacterial survival. Thus, a single inhibitory lectin receptor detects two distinct glycan "self-associated molecular patterns" to maintain neutrophil homeostasis, and two leading human bacterial pathogens have independently evolved molecular mimicry to exploit this immunoregulatory mechanism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Secundino, Ismae ...
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Lizcano, Anel
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Roupé, Markus
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Wang, Xiaoxia
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Cole, Jason N
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Olson, Joshua
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visa fler...
-
Ali, S Raza
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Dahesh, Samira
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Amayreh, Lenah K
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Henningham, Anna
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Varki, Ajit
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Nizet, Victor
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Immunologi inom ...
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Journal of Molec ...
- Av lärosätet
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Lunds universitet