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New device, ‘old’ a...
New device, ‘old’ allergens. Allergic contact dermatitis caused by the Dexcom G7 glucose sensor
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- Mowitz, Martin (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Dermatologi,Occupational and Environmental Dermatology,Lund University Research Groups,Dermatology,Skåne University Hospital
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- Hosseini, Sarah (författare)
- Skåne University Hospital,Lund University,Ryhov County Hospital, Jönköping
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- Siemund, Ingrid (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital
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visa fler...
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- Ulriksdotter, Josefin (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital
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- Svedman, Cecilia (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital
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visa färre...
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(creator_code:org_t)
- Engelska.
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Ingår i: Contact Dermatitis. - 0105-1873.
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Allergic contact dermatitis (ACD) has been reported as an adverse effect from the use of several glucose sensors and insulin pumps from different manufacturers. Isobornyl acrylate (IBOA) has been identified as a major culprit sensitizer, but also other acrylates and (modified) colophonium have been reported as causes of ACD. Objectives: To report the two first cases diagnosed with ACD caused by the Dexcom G7 (DG7) glucose sensor. Patients and Methods: Two children with suspected ACD from DG7 were patch tested with our medical device series with an addition of selected test preparations including two variants of modified colophonium – methyl hydrogenated rosinate (MHR) and glyceryl hydrogenated rosinate (GHR). Both patients were also tested with acetone extracts made from different parts of the DG7 sensor. The extracts were analysed by gas chromatography–mass spectrometry (GC–MS). Results: Both patients tested positive to IBOA, hydroabietyl alcohol and GHR. In addition, patient 1 had a positive reaction to MHR and patient 2 had a positive reaction to colophonium. The GC–MS analyses showed the presence of IBOA and colophonium-related substances in the DG7 extracts. Conclusions: Both patients were diagnosed with contact allergy to well-known medical device-related sensitizers. The presence of IBOA and (modified) colophonium in a newly introduced (on the Swedish market in 2023) glucose sensor is remarkable and indicates an inadequate toxicological assessment of the materials used in the sensor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- allergic contact dermatitis
- case report
- colophonium
- Dexcom G7
- glucose sensor
- glyceryl hydrogenated rosinate
- hydroabietyl alcohol
- isobornyl acrylate
- medical device
- methyl hydrogenated rosinate
- rosin
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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