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Neonatal BCG vaccin...
Neonatal BCG vaccination and child survival in TB-exposed and TB-unexposed children : A prospective cohort study
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- Thysen, Sanne M. (författare)
- Aarhus University,Danish Serum Institute, Copenhagen,University of Southern Denmark,Bandim Health Project
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- Benn, Christine Stabell (författare)
- Danish Serum Institute, Copenhagen,University of Southern Denmark,Bandim Health Project
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- Gomes, Victor Francisco (författare)
- Bandim Health Project
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- Rudolf, Frauke (författare)
- Aarhus University Hospital,Bandim Health Project
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- Wejse, Christian (författare)
- Aarhus University Hospital,Bandim Health Project,Aarhus University
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- Roth, Adam (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Public Health Agency of Sweden
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- Kallestrup, Per (författare)
- Aarhus University
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- Aaby, Peter (författare)
- Danish Serum Institute, Copenhagen,Bandim Health Project
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- Fisker, Ane (författare)
- Danish Serum Institute, Copenhagen,Bandim Health Project
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(creator_code:org_t)
- 2020-02-28
- 2020
- Engelska.
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 10:2
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https://bmjopen.bmj....
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children entered the analysis when their vaccination card was inspected after 28 days of age and remained under surveillance to 3 years of age. Children residing in the same house as a TB case were classified as TB-exposed from 3 months prior to case registration to the end of follow-up. Methods Using Cox-proportional hazards models with age as underlying time scale, we compared mortality of children with and without neonatal BCG between October 2003 and September 2017. Main outcome measure HR for neonatal BCG compared with no neonatal BCG by TB-exposure status. Results Among the 39 421 children who entered the analyses, 3022 (8%) had observation time as TB-exposed. In total, 84% of children received neonatal BCG. Children with neonatal BCG had lower mortality both in TB-exposed (adjusted HR: 0.57 (0.26 to 1.27)) and in TB-unexposed children (HR: 0.57 (95% CI 0.47 to 0.69)) than children without neonatal BCG. Children exposed to TB had higher mortality than TB-unexposed children if they had not received neonatal BCG. Conclusion Neonatal BCG vaccination was associated with lower mortality among both TB-exposed and TB-unexposed children, consistent with neonatal BCG vaccination having beneficial non-specific effects. Interventions to increase timely BCG vaccination are urgently warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- epidemiology
- paediatric infectious disease & immunisation
- public health
- tuberculosis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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