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Nano-Hydroxyapatite...
Nano-Hydroxyapatite Bone Substitute Functionalized with Bone Active Molecules for Enhanced Cranial Bone Regeneration
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- Teotia, Arun Kumar (författare)
- Indian Institute of Technology Kanpur
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- Raina, Deepak Bushan (författare)
- Lund University,Lunds universitet,Klinisk och experimentell benläkning,Forskargrupper vid Lunds universitet,Clinical and experimental bone healing,Lund University Research Groups
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- Singh, Chandan (författare)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences
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- Sinha, Neeraj (författare)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences
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- Isaksson, Hanna (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Lund University Research Groups
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- Tägil, Magnus (författare)
- Lund University,Lunds universitet,Klinisk och experimentell benläkning,Forskargrupper vid Lunds universitet,Clinical and experimental bone healing,Lund University Research Groups
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- Lidgren, Lars (författare)
- Lund University,Lunds universitet,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Kumar, Ashok (författare)
- Indian Institute of Technology Kanpur
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(creator_code:org_t)
- 2017-02-20
- 2017
- Engelska 13 s.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 9:8, s. 6816-6828
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to synthesize and characterize a nano-hydroxyapatite (nHAP) and calcium sulfate bone substitute (NC) for cranioplasty. The NC was functionalized with low concentrations of bone morphogenetic protein-2 (BMP-2) and zoledronic acid (ZA) and characterized both in vitro and in vivo. In vitro studies included MTT, ALP assays, and fluorescent staining of Saos-2 (human osteoblasts) and MC3T3-E1 (murine preosteoblasts) cells cultured on NC. An in vivo study divided 20 male Wistar rats into four groups: control (defect only), NC, NC + ZA, and NC + ZA + rhBMP-2. The materials were implanted in an 8.5 mm critical size defect in the calvarium for 12 weeks. Micro-CT quantitative analysis was carried out in vivo at 8 weeks and ex vivo after 12 weeks. Mineralization was highest in the NC + ZA + rhBMP-2 group (13.0 ± 2.8 mm3) compared to the NC + ZA group (9.0 ± 3.2 mm3), NC group (6.4 ± 1.9 mm3), and control group (3.4 ± 1.0 mm3) after 12 weeks. Histological and spectroscopic analysis of the defect site provided a qualitative confirmation of neo-bone, which was in agreement with the micro-CT results. In conclusion, NC can be used as a carrier for bioactive molecules, and functionalization with rhBMP-2 and ZA in low doses enhances bone regeneration.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Nyckelord
- bisphosphonates
- bone morphogenetic proteins
- cranial model
- nano-hydroxyapatite
- osteoinductive
- solid state NMR
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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