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Gut-associated lymp...
Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity
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- Bemark, Mats (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Translational Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Sahlgrenska University Hospital
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- Pitcher, Michael J (författare)
- King's College London
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- Dionisi, Chiara (författare)
- King's College London
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- Spencer, Jo (författare)
- King's College London
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Trends in Immunology. - 1471-4981. ; 45:3, s. 211-223
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT and other lymphoid tissues. For example, GALT propagates IgA responses against glycans that show signs of having been generated in germinal centers. Other findings suggest that humans are among those species where GALT supports the diversification, propagation, and possibly selection of systemic B cells. Here, we review novel findings that identify GALT as distinctive, and able to support these processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
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