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Association of estr...
Association of estrogen receptor-alpha A908G (K303R) mutation with breast cancer risk
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Abbasi, Sakineh (författare)
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Rasouli, Mina (författare)
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- Nouri, Mehrnaz (författare)
- Lund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science
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Kalbasi, Samira (författare)
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(creator_code:org_t)
- 2013
- 2013
- Engelska.
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Ingår i: International Journal of Clinical and Experimental Medicine. - 1940-5901. ; 6:1, s. 39-49
- Relaterad länk:
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http://www.ncbi.nlm.... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Genetic mutations in premalignant breast lesions may have a role in malignancy progression or influence the behavior of subsequent disease. A point mutation in estrogen receptor-alpha (ER-&ALPHA) as A908G (Lys303 -> Arg) was originally involved to hypersensitive to estrogen breast hyperplasia. We detected this mutation among Iranian women with invasive breast cancer. A population-based case-control study was conducted in 150 newly diagnosed invasive breast cancer and 147 healthy control individuals controls to screen for presence of the ER-alpha A908G mutation by using single-strand conformation polymorphism (SSCP) analysis and 33Pcycle DNA sequencing. We detected the 10.7% ER-alpha A908G mutation in the form of heterozygote genotype only among cancer patients (chi(2)=22.752, P=0.00). The allelic frequency of mutant allele AGG in codon 303 was significantly (chi(2)=29.709, P=0.001) higher in patients with the family history of breast cancer (28.9%) than those without the family history of breast cancer (1.9%). Our data suggest that ER-alpha codon 303 mutation is correlated with various aspects of breast cancer in Iran. ER-alpha genotype might represent a surrogate marker for predicting breast cancer developing later in life.
Ämnesord
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Nyckelord
- Breast cancer
- mutation
- estrogen receptor
- PCR-SSCP
- lymph node
- metastasis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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