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Formation of the bi...
Formation of the bicoid morphogen gradient: an mRNA gradient dictates the protein gradient
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Spirov, Alexander (författare)
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- Fahmy, Khalid (författare)
- Lund University,Lunds universitet,Utvecklingsbiologi i invertebrater, Stefan Baumgartners grupp,Forskargrupper vid Lunds universitet,Invertebrate Developmental Biology, Stefan Baumgartner's group,Lund University Research Groups
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- Schneider, Martina (författare)
- Lund University,Lunds universitet,Utvecklingsbiologi i invertebrater, Stefan Baumgartners grupp,Forskargrupper vid Lunds universitet,Invertebrate Developmental Biology, Stefan Baumgartner's group,Lund University Research Groups
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Frei, Erich (författare)
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Noll, Markus (författare)
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- Baumgartner, Stefan (författare)
- Lund University,Lunds universitet,Utvecklingsbiologi i invertebrater, Stefan Baumgartners grupp,Forskargrupper vid Lunds universitet,Invertebrate Developmental Biology, Stefan Baumgartner's group,Lund University Research Groups
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(creator_code:org_t)
- The Company of Biologists, 2009
- 2009
- Engelska.
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Ingår i: Development: For advances in developmental biology and stem cells. - : The Company of Biologists. - 1477-9129. ; 136:4, s. 605-614
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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http://dev.biologist...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this observation by showing that the bcd mRNA and Bcd protein gradient profiles are virtually identical at all times. This confirms our previous conclusion that the Bcd gradient is produced by a bcd mRNA gradient rather than by diffusion. Based on our observation that bcd mRNA colocalizes with Staufen ( Stau), we propose that the bcd mRNA gradient forms by a novel mechanism involving quasi-random active transport of a Stau-bcd mRNA complex through a nonpolar microtubular network, which confines the bcd mRNA to the cortex of the embryo.
Ämnesord
- NATURVETENSKAP -- Biologi -- Utvecklingsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Developmental Biology (hsv//eng)
Nyckelord
- Morphogenetic gradient
- Staufen
- bicoid
- ARTS model
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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