Survival of Patients With Angina Pectoris Undergoing Percutaneous Coronary Intervention With Intracoronary Pressure Wire Guidance

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Survival of Patients With Angina Pectoris Undergoing Percutaneous Coronary Intervention With Intracoronary Pressure Wire Guidance

Völz, Sebastian (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

Dworeck, Christian (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

Redfors, Björn (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

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Pétursson, Pétur (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

Angerås, Oskar (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

Gan, Li Ming (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden; Early Clinical Development, Early CardioVascular, Renal and Metabolism, R&D BioPharmaceuticals, AstraZeneca, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.;AstraZeneca, R&D BioPharmaceut, Early Clin Dev, Early CardioVasc Renal & Metab, Gothenburg, Sweden.

Götberg, Matthias (författare): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Clin Sci, Dept Cardiol, Lund, Sweden.

Sarno, Giovanna (författare): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala University Hospital

Venetsanos, Dimitrios (författare): Karolinska Institutet

Grimfärd, Per (författare): Västmanland Hospital,Department of Internal Medicine, Västmanlands Sjukhus, Västerås, Sweden,Vastmanlands Sjukhus, Dept Internal Med, Vasteras, Sweden.

Hofmann, Robin (författare): Karolinska Institutet,Karolinska Institute,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Div Cardiol, Stockholm, Sweden.

Jensen, Jens (författare): Karolinska Institutet,Karolinska Institute,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden; Unit of Cardiology, Capio St. Görans Sjukhus, Stockholm, Sweden,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Div Cardiol, Stockholm, Sweden.;Capio St Gorans Sjukhus, Unit Cardiol, Stockholm, Sweden.

Björklund, Fredrik (författare): Department of Cardiology, Östersund Hospital, Östersund, Sweden,Ostersund Hosp, Dept Cardiol, Ostersund, Sweden.

Danielewicz, Mikael (författare): Department of Cardiology, PCI-Unit at Karlstad Hospital, Karlstad, Sweden,Karlstad Hosp, PCI Unit, Dept Cardiol, Karlstad, Sweden.

Linder, Rickard (författare): Karolinska Institutet

Råmunddal, Truls (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

Fröbert, Ole, 1964- (författare): Örebro universitet,Örebro University,Institutionen för medicinska vetenskaper,Department of Cardiology,Orebro Univ, Fac Hlth, Dept Cardiol, Orebro, Sweden.

Witt, Nils (författare): Karolinska Institutet,Karolinska Institute,Department of Clinical Science and Education, Division of Cardiology, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Div Cardiol, Stockholm, Sweden.

James, Stefan, 1964- (författare): Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital

Erlinge, David (författare): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Clin Sci, Dept Cardiol, Lund, Sweden.

Omerovic, Elmir (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

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Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden (creator_code:org_t)

Elsevier BV, 2020
2020
Engelska 15 s.
Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 75:22, s. 2785-2799

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Background: Intracoronary pressure wire measurement of fractional flow reserve (FFR) provides decision-making guidance during percutaneous coronary intervention (PCI). However, limited data exist on the effect of FFR on long-term clinical outcomes in patients with stable angina pectoris. Objectives: The purpose of this study was to determine the association between the usage of FFR and all-cause mortality in patients with stable angina undergoing PCI. Methods: Data was used from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) on all patients undergoing PCI (with or without FFR guidance) for stable angina pectoris in Sweden between January 2005 and March 2016. The primary endpoint was all-cause mortality, and the secondary endpoints were stent thrombosis (ST) or restenosis and peri-procedural complications. The primary model was multilevel Cox proportional hazards regression adjusted with Kernel-based propensity score matching. Results: In total, 23,860 patients underwent PCI for stable angina pectoris; of these, FFR guidance was used in 3,367. After a median follow-up of 4.7 years (range 0 to 11.2 years), the FFR group had lower adjusted risk estimates for all-cause mortality (hazard ratio: 0.81; 95% confidence interval [CI]: 0.73 to 0.89; p < 0.001), and ST and restenosis (hazard ratio: 0.74; 95% CI: 0.57 to 0.96; p = 0.022). The number of peri-procedural complications did not differ between the groups (adjusted odds ratio: 0.96; 95% CI: 0.77 to 1.19; p = 0.697). Conclusions: In this observational study, the use of FFR was associated with a lower risk of long-term mortality, ST, and restenosis in patients undergoing PCI for stable angina pectoris. This study supports the current European and American guidelines for the use of FFR during PCI and shows that intracoronary pressure wire guidance confers prognostic benefit in patients with stable angina pectoris.

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Survival of Patients With Angina Pectoris Undergoing Percutaneous Coronary Intervention With Intracoronary Pressure Wire Guidance

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