Sökning: id:"swepub:oai:lup.lub.lu.se:96c5e0ab-33d4-41d7-b60b-70fef43b99c7" >
Metformin is the ke...
Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes : A nested, case–control study
-
- Natali, Andrea (författare)
- University of Pisa
-
- Nesti, Lorenzo (författare)
- University of Pisa
-
- Venturi, Elena (författare)
- University of Pisa
-
visa fler...
-
- Shore, Angela C. (författare)
- University of Exeter
-
- Khan, Faisel (författare)
- University of Dundee
-
- Gooding, Kim (författare)
- University of Exeter
-
- Gates, Phillip E. (författare)
- University of Exeter
-
- Looker, Helen C. (författare)
- University of Dundee
-
- Dove, Fiona (författare)
- University of Dundee
-
- Goncalves, Isabel (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - translationella studier,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups,Cardiovascular Research - Translational Studies
-
- Persson, Margaretha (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
-
- Nilsson, Jan (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
-
- 2018-10-02
- 2019
- Engelska.
-
Ingår i: Diabetes, Obesity and Metabolism. - : Wiley. - 1462-8902. ; 21:2, s. 412-416
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://discovery.du...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Produced as a tissue defence response to hypoxia and inflammation, growth differentiation factor-15 (GDF-15) is elevated in people receiving metformin treatment. To gain insight into the relationship of GDF-15 with metformin and major cardiovascular risk factors, we analysed the data from the SUMMIT cohort (n = 1438), a four-centre, nested, case–control study aimed at verifying whether biomarkers of atherosclerosis differ according to the presence of type 2 diabetes and cardiovascular disease. While in univariate analysis, major cardiovascular risk factors, with the exception of gender and cholesterol, increased similarly and linearly across GDF-15 quartiles, the independent variables associated with GDF-15, both in participants with and without diabetes, were age, plasma creatinine, N-terminal pro-brain natriuretic peptide, diuretic use, smoking exposure and glycated haemoglobin. In participants with diabetes, metformin treatment was associated with a 40% rise in GDF-15 level, which was independent of the other major factors, and largely explained their elevated GDF-15 levels. The relatively high GDF-15 bioavailability might partly explain the protective cardiovascular effects of metformin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cardiovascular disease
- GDF-15
- growth differentiation factor-15
- metformin
- type 2 diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Natali, Andrea
-
Nesti, Lorenzo
-
Venturi, Elena
-
Shore, Angela C.
-
Khan, Faisel
-
Gooding, Kim
-
visa fler...
-
Gates, Phillip E ...
-
Looker, Helen C.
-
Dove, Fiona
-
Goncalves, Isabe ...
-
Persson, Margare ...
-
Nilsson, Jan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Diabetes, Obesit ...
- Av lärosätet
-
Lunds universitet