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Physical fitness am...
Physical fitness among swedish military conscripts and long-term risk for type 2 diabetes mellitus a cohort study
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- Crump, Casey (författare)
- Icahn School of Medicine at Mount Sinai
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- Sundquist, Jan (författare)
- Lund University,Lunds universitet,CRC, Clinical Research Centre,Medicinska fakulteten,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,CRC, Clinical Research Centre,Faculty of Medicine,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Winkleby, Marilyn A. (författare)
- Stanford University
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- Sieh, Weiva (författare)
- Icahn School of Medicine at Mount Sinai
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- Sundquist, Kristina (författare)
- Lund University,Lunds universitet,CRC, Clinical Research Centre,Medicinska fakulteten,CRC, Clinical Research Centre,Faculty of Medicine
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(creator_code:org_t)
- 2016
- 2016
- Engelska 8 s.
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Ingår i: Annals of Internal Medicine. - 0003-4819. ; 164:9, s. 577-584
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- Background: Early-life physical fitness has rarely been examined in relation to type 2 diabetes mellitus (DM) in adulthood because of the lengthy follow-up required. Elucidation of modifiable risk factors at young ages may help facilitate earlier and more effective interventions. Objective: To examine aerobic capacity and muscle strength at age 18 years in relation to risk for type 2 DM in adulthood. Design: National cohort study. Setting: Sweden. Participants: 1 534 425 military conscripts from 1969 to 1997 (97% to 98% of all men aged 18 years nationwide) without prior type 2 DM. Measurements: Aerobic capacity and muscle strength (measured in watts and newtons per kilogram of body weight, respectively) were examined in relation to type 2 DM identified from outpatient and inpatient diagnoses from 1987 to 2012 (maximum age, 62 years). Results: 34 008 men were diagnosed with type 2 DM in 39.4 million person-years of follow-up. Low aerobic capacity and muscle strength were independently associated with increased risk for type 2 DM. The absolute difference in cumulative incidence of type 2 DM between the lowest and highest tertiles of both aerobic capacity and strength was 0.22% at 20 years of follow-up (95% CI, 0.20% to 0.25%), 0.76% at 30 years (CI, 0.71% to 0.81%), and 3.97% at 40 years (CI, 3.87% to 4.06%). Overall, the combination of low aerobic capacity and muscle strength was associated with a 3-fold risk for type 2 DM(adjusted hazard ratio, 3.07 [CI, 2.88 to 3.27]; P <0.001), with a positive additive interaction (P <0.001). These associations were seen even among men with normal body mass index. Limitation: This cohort did not include women and did not measure physical fitness at older ages. Conclusion: In this large cohort of Swedish male military conscripts, low aerobic capacity and muscle strength at age 18 years were associated with increased long-term risk for type 2 DM, even among those with normal body mass index. Primary Funding Source: National Institutes of Health.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (ämneskategori)
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