Biodegradation and biocompatability of a calcium sulphate-hydroxyapatite bone substitute.

• An injectable material consisting of calcium sulphate mixed with hydroxyapatite was investigated as a possible alternative to autograft in the restoration of bone defects. The material was studied both in vitro in simulated body fluid (SBF) and in vivo when implanted in rat muscles and into the proximal tibiae of rabbits. Variation in the strength and weight of the material during ageing in SBF was measured. Tissue response, material resorption and bone ingrowth were studied in the animal models. A good tissue response was observed in both the rat muscles and rabbit tibiae without inflammatory reactions or the presence of fibrous tissue. Ageing in SBF showed that during the first week carbonated hydroxyapatite precipitated on the surfaces of the material and this may enhance bone ingrowth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)

Nyckelord

Bone Substitutes

Biodegradation

Animals

Electron

Muscle

Rats

Rabbits

Skeletal: metabolism

Sprague-Dawley

Scanning

Tibia: metabolism

Calcium Sulfate: metabolism

Durapatite: metabolism

Microscopy

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)