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Cannabidiol, a Majo...
Cannabidiol, a Major Non‐Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
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Kogan, Natalya M (författare)
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Melamed, Eitan (författare)
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Wasserman, Elad (författare)
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visa fler...
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Raphael, Bitya (författare)
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Breuer, Aviva (författare)
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Stok, Kathryn S (författare)
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Sondergaard, Rachel (författare)
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Escudero, Ana VVillarreal (författare)
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Baraghithy, Saja (författare)
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Attar‐Namdar, Malka (författare)
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Friedlander‐Barenboim, Silvina (författare)
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- Mathavan, Neashan (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Isaksson, Hanna (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Mechoulam, Raphael (författare)
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Müller, Ralph (författare)
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Bajayo, Alon (författare)
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Gabet, Yankel (författare)
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Bab, Itai (författare)
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(creator_code:org_t)
- 2015-05-10
- 2015
- Engelska.
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Ingår i: Journal of Bone and Mineral Research. - : Wiley. - 1523-4681 .- 0884-0431. ; 30:10, s. 1905-1913
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cannabinoid ligands regulate bone mass, but skeletal effects of cannabis (marijuana and hashish) have not been reported. Bone fractures are highly prevalent, involving prolonged immobilization and discomfort. Here we report that the major non-psychoactive cannabis constituent, cannabidiol (CBD), enhances the biomechanical properties of healing rat mid-femoral fractures. The maximal load and work-to-failure, but not the stiffness, of femurs from rats given a mixture of CBD and Δ9-tetrahydrocannabinol (THC) for 8 weeks were markedly increased by CBD. This effect is not shared by THC (the psychoactive component of cannabis), but THC potentiates the CBD stimulated work-to-failure at 6 weeks postfracture followed by attenuation of the CBD effect at 8 weeks. Using micro–computed tomography (μCT), the fracture callus size was transiently reduced by either CBD or THC 4 weeks after fracture but reached control level after 6 and 8 weeks. The callus material density was unaffected by CBD and/or THC. By contrast, CBD stimulated mRNA expression of Plod1 in primary osteoblast cultures, encoding an enzyme that catalyzes lysine hydroxylation, which is in turn involved in collagen crosslinking and stabilization. Using Fourier transform infrared (FTIR) spectroscopy we confirmed the increase in collagen crosslink ratio by CBD, which is likely to contribute to the improved biomechanical properties of the fracture callus. Taken together, these data show that CBD leads to improvement in fracture healing and demonstrate the critical mechanical role of collagen crosslinking enzymes. © 2015 American Society for Bone and Mineral Research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- μCT
- FTIR
- FRACTURE HEALING
- COLLAGEN CROSSLINKING
- LYSYL HYDROXYLASE
- CANNABIDIOL
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Kogan, Natalya M
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Melamed, Eitan
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Wasserman, Elad
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Raphael, Bitya
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Breuer, Aviva
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Stok, Kathryn S
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visa fler...
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Sondergaard, Rac ...
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Escudero, Ana VV ...
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Baraghithy, Saja
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Attar‐Namdar, Ma ...
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Friedlander‐Bare ...
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Mathavan, Neasha ...
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Isaksson, Hanna
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Mechoulam, Rapha ...
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Müller, Ralph
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Bajayo, Alon
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Gabet, Yankel
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Bab, Itai
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
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Journal of Bone ...
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Lunds universitet