Sökning: id:"swepub:oai:lup.lub.lu.se:a125c62e-84e3-493d-9d24-57fe8de883cd" >
An investigation in...
An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia : a multi-center study of 381 patients
-
- Nahi, Hareth (författare)
- Karolinska Institutet,Department of Haematology, Karolinska University Hospital, Sweden, Haematology Centre, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden
-
- Hägglund, Hans (författare)
- Karolinska Institutet,Hägglund, H., Department of Haematology, Karolinska University Hospital, Sweden,Hallböök, H., Department of Haematology, Uppsala University Hospital, Sweden
-
- Ahlgren, Thomas (författare)
- Skåne University Hospital,Department of Haematology, Malmö University Hospital, Sweden
-
visa fler...
-
- Bernell, Per (författare)
- Department of Haematology, Karolinska University Hospital, Sweden
-
- Hardling, Mats (författare)
- Department of Haematology, Sahlgrenska University Hospital, Sweden
-
- Karlsson, Karin (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Department of Haematology, Lund University Hospital, Sweden
-
- Lazarevic, Vladimir Lj (författare)
- Umeå universitet,Medicin,Norrland University Hospital,Department of Haematology, Umeå University Hospital, Sweden
-
- Linderholm, Mats (författare)
- Östergötlands Läns Landsting,Hematologiska kliniken
-
- Smedmyr, Bengt (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Blodsjukdomar,Department of Haematology, Uppsala University Hospital, Sweden
-
- Aström, Maria (författare)
- Åström, M., Department of Hematology, Örebro University Hospital, Sweden
-
- Hallböök, Helene (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Blodsjukdomar
-
visa färre...
-
(creator_code:org_t)
- 2008-09-11
- 2008
- Engelska 5 s.
-
Ingår i: Haematologica. - Pavia : Ferrata Storti Foundation (Haematologica). - 1592-8721 .- 0390-6078. ; 93:11, s. 8-1734
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://doi.org/10.3...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Aged
- Burkitt Lymphoma
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 22
- Chromosomes, Human, Pair 9
- Genetic Markers
- Humans
- Karyotyping
- Leukocyte Count
- Middle Aged
- Prognosis
- Sequence Deletion
- Survival Analysis
- Translocation, Genetic
- World Health Organization
- p14ARF
- MEDICINE
- NATURAL SCIENCES
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Nahi, Hareth
-
Hägglund, Hans
-
Ahlgren, Thomas
-
Bernell, Per
-
Hardling, Mats
-
Karlsson, Karin
-
visa fler...
-
Lazarevic, Vladi ...
-
Linderholm, Mats
-
Smedmyr, Bengt
-
Aström, Maria
-
Hallböök, Helene
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Haematologica
- Av lärosätet
-
Lunds universitet
-
Umeå universitet
-
Uppsala universitet
-
Karolinska Institutet
-
Linköpings universitet