The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies.

• Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of the disease-causing gene in 1993, a number of genetically modified animal models of HD have been generated. The first transgenic mouse models, R6/1 and R6/2 lines, were established 8 years ago. The R6/2 mice have been the best characterized and the most widely used model to study pathogenesis of HD and therapeutic interventions. In the present review, we especially focus on the characteristics of R6 transgenic mouse models and, in greater detail, describe the different therapeutic strategies that have been tested in these mice. We also, at the end, critically assess the relevance of the HD mouse models compared with the human disease and discuss how they can be best used in the future.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Huntington Disease: psychology

Huntington Disease: therapy

Mice

Huntington Disease: pathology

Behavior

Animal

Humans

Huntington Disease: diet therapy

Huntington Disease: genetics

Animals

Anti-Inflammatory Agents: therapeutic use

Apoptosis: drug effects

Brain: pathology

Disease Models

Transgenic: physiology

Protease Inhibitors: therapeutic use

Protein Folding

Research Support

Non-U.S. Gov't

Tissue Therapy

Transglutaminases: antagonists & inhibitors

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)