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Subgroups of patien...
Subgroups of patients with young-onset type 2 diabetes in India reveal insulin deficiency as a major driver
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- Prasad, Rashmi B (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Asplund, Olof (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Shukla, Sharvari R (författare)
- King Edward Memorial Hospital and Research Centre
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- Wagh, Rucha (författare)
- King Edward Memorial Hospital and Research Centre
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- Kunte, Pooja (författare)
- King Edward Memorial Hospital and Research Centre
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- Bhat, Dattatrey (författare)
- King Edward Memorial Hospital and Research Centre
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- Parikh, Malay (författare)
- Dia Care - Diabetes Hormone Clinic
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- Shah, Meet (författare)
- Dia Care - Diabetes Hormone Clinic
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- Phatak, Sanat (författare)
- King Edward Memorial Hospital and Research Centre
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- Käräjämäki, Annemari (författare)
- Vaasa Central Hospital
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- Datta, Anupam (författare)
- Assam Medical College and Hospital
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- Kakati, Sanjeeb (författare)
- Assam Medical College and Hospital
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- Tuomi, Tiinamaija (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Folkhälsan Research Center,Helsinki University Central Hospital
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- Saboo, Banshi (författare)
- Dia Care - Diabetes Hormone Clinic
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Yajnik, Chittaranjan S (författare)
- King Edward Memorial Hospital and Research Centre
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(creator_code:org_t)
- 2021-10-23
- 2022
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 65:1, s. 65-78
- Relaterad länk:
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http://dx.doi.org/10... (free)
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Abstract
Ämnesord
Stäng
- AIM/HYPOTHESIS: Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping in Indian individuals with young-onset type 2 diabetes.METHODS: We applied the European-derived centroids to Indian individuals with type 2 diabetes diagnosed before 45 years of age from the WellGen cohort (n = 1612). We also applied de novo k-means clustering to the WellGen cohort to validate the subgroups. We then compared clinical and metabolic-endocrine characteristics and the complication rates between the subgroups. We also compared characteristics of the WellGen subgroups with those of two young European cohorts, ANDIS (n = 962) and DIREVA (n = 420). Subgroups were also assessed in two other Indian cohorts, Ahmedabad (n = 187) and PHENOEINDY-2 (n = 205).RESULTS: Both Indian and European young-onset type 2 diabetes patients were predominantly classified into severe insulin-deficient (SIDD) and mild obesity-related (MOD) subgroups, while the severe insulin-resistant (SIRD) and mild age-related (MARD) subgroups were rare. In WellGen, SIDD (53%) was more common than MOD (38%), contrary to findings in Europeans (Swedish 26% vs 68%, Finnish 24% vs 71%, respectively). A higher proportion of SIDD compared with MOD was also seen in Ahmedabad (57% vs 33%) and in PHENOEINDY-2 (67% vs 23%). Both in Indians and Europeans, the SIDD subgroup was characterised by insulin deficiency and hyperglycaemia, MOD by obesity, SIRD by severe insulin resistance and MARD by mild metabolic-endocrine disturbances. In WellGen, nephropathy and retinopathy were more prevalent in SIDD compared with MOD while the latter had higher prevalence of neuropathy.CONCLUSIONS /INTERPRETATION: Our data identified insulin deficiency as the major driver of type 2 diabetes in young Indians, unlike in young European individuals in whom obesity and insulin resistance predominate. Our results provide useful clues to pathophysiological mechanisms and susceptibility to complications in type 2 diabetes in the young Indian population and suggest a need to review management strategies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ANDIS
- diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Prasad, Rashmi B
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Asplund, Olof
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Shukla, Sharvari ...
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Wagh, Rucha
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Kunte, Pooja
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Bhat, Dattatrey
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visa fler...
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Parikh, Malay
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Shah, Meet
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Phatak, Sanat
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Käräjämäki, Anne ...
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Datta, Anupam
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Kakati, Sanjeeb
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Tuomi, Tiinamaij ...
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Saboo, Banshi
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Ahlqvist, Emma
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Groop, Leif
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Yajnik, Chittara ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetologia
- Av lärosätet
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Lunds universitet