Isolation and partial characterization of a low molecular weight trypsin inhibitor from human urine

• A low molecular weight glycoprotein which completely inhibited trypsin at a 1 : 1 molar ratio was isolated from human urine. It was generated from a precursor molecule which in turn derived from plasma inter-alpha-trypsin inhibitor. It had one polypeptide chain with a molecular weight of about 20 000 and a high content of half-cystine residues. Its amino-terminal amino-acid sequence was Val-Thr-Glu-Val-Thr-X-Leu-Glu-Asp-.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Alpha-Globulins/metabolism

Amino Acid Sequence

Carbohydrates/analysis

Glycoproteins/urine

Humans

Immunoelectrophoresis

Kidney Tubules

Molecular Weight

Oxidation-Reduction

Proteinuria/urine

Trypsin Inhibitors/isolation & purification

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)