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Genetic diversity i...
Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma
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Abdel-Hamid, Mohamed (author)
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El-Daly, Mai (author)
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Molnegren, Vilma (author)
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El-Kafrawy, Sherif (author)
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Abdel-Latif, Sohair (author)
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Esmat, Gamal (author)
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Strickland, G. Thomas (author)
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Loffredo, Christopher (author)
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- Albert, Jan (author)
- Karolinska Institutet
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- Widell, Anders (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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(creator_code:org_t)
- Microbiology Society, 2007
- 2007
- English.
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In: Journal of General Virology. - : Microbiology Society. - 1465-2099 .- 0022-1317. ; 88:5, s. 1526-1531
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Abstract
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- Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length polymorphism and phylogenetic analyses of sequences from the mid-core and non-structural 5B regions. The different genotyping methods showed good agreement. The majority of the viruses (83 of 131; 63 %) were of subtype 4a, but five other subtypes within genotype 4 were also observed, as well as three genotype 1b, five genotype 1g and one genotype 3a samples. Interestingly, subtype 4o, which was easily identifiable in all three genomic regions, 3 showed an association with HCC (P=0.017), which merits further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Abdel-Hamid, Moh ...
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El-Daly, Mai
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Molnegren, Vilma
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El-Kafrawy, Sher ...
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Abdel-Latif, Soh ...
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Esmat, Gamal
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show more...
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Strickland, G. T ...
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Loffredo, Christ ...
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Albert, Jan
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Widell, Anders
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Journal of Gener ...
- By the university
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Lund University
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Karolinska Institutet