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Neurotensin is a li...
Neurotensin is a lipid-induced gastrointestinal peptide associated with visceral adipose tissue inflammation in obesity
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- Barchetta, Ilaria (författare)
- Sapienza University of Rome
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- Cimini, Flavia Agata (författare)
- Sapienza University of Rome
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- Capoccia, Danila (författare)
- Sapienza University of Rome
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- Bertoccini, Laura (författare)
- Sapienza University of Rome
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- Ceccarelli, Valentina (författare)
- Sapienza University of Rome
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- Chiappetta, Caterina (författare)
- Sapienza University of Rome
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- Leonetti, Frida (författare)
- Sapienza University of Rome
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- Di Cristofano, Claudio (författare)
- Sapienza University of Rome
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- Silecchia, Gianfranco (författare)
- Sapienza University of Rome
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- Orho-Melander, Marju (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Cavallo, Maria Gisella (författare)
- Sapienza University of Rome
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(creator_code:org_t)
- 2018-04-23
- 2018
- Engelska.
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 10:4
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Neurotensin (NT) is a 13-amino acid peptide localized in the neuroendocrine cells of the small intestine, which promotes fat absorption and fatty acids translocation in response to lipid ingestion. NT-knock-out mice fed with a high-fat diet are protected from obesity, fatty liver, and the development of insulin-resistance. In humans, higher plasma levels of pro-NT, which is the stable circulating precursor of NT, predict obesity, type 2 diabetes (T2D), and cardiovascular disease. In obesity, the presence of visceral adipose tissue (VAT) inflammation leads to unfavorable metabolic outcomes and is associated with the development of T2D and non-alcoholic fatty liver disease (NAFLD). In this study, we investigated the relationship between plasma pro-NT levels and the presence of VAT inflammation in biopsies from 40 morbidly obese subjects undergoing bariatric surgery. We demonstrated that higher proNT levels are significantly associated with greater macrophages infiltration, HIF-1α, WISP-1, and UNC5B expression in VAT (all p < 0.01) due to the diagnosis of T2D and NAFLD. The overall results show that, in obesity, pro-NT is a biomarker of VAT inflammation and insulin-resistance. Additionally, NT may be involved in the development of dysmetabolic conditions likely mediated by increased gut fat absorption and the presence of a proinflammatory milieu in the adipose tissue.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Adipose tissue inflammation
- Lipids
- Obesity
- Proneurotensin
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Barchetta, Ilari ...
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Cimini, Flavia A ...
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Capoccia, Danila
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Bertoccini, Laur ...
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Ceccarelli, Vale ...
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Chiappetta, Cate ...
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visa fler...
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Leonetti, Frida
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Di Cristofano, C ...
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Silecchia, Gianf ...
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Orho-Melander, M ...
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Melander, Olle
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Cavallo, Maria G ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Nutrients
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