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Metabolic and prote...
Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population
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- Zaghlool, Shaza B. (författare)
- Weill Cornell Medicine, Qatar
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- Halama, Anna (författare)
- Weill Cornell Medicine, Qatar
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- Stephan, Nisha (författare)
- Weill Cornell Medicine, Qatar
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- Gudmundsdottir, Valborg (författare)
- University of Iceland,Icelandic Heart Association
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- Gudnason, Vilmundur (författare)
- Icelandic Heart Association,University of Iceland
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- Jennings, Lori L. (författare)
- Novartis Institutes for BioMedical Research, Inc.
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- Thangam, Manonanthini (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Malik, Rayaz A. (författare)
- Weill Cornell Medicine, Qatar
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- Albagha, Omar M.E. (författare)
- University of Edinburgh
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- Abou‑Samra, Abdul Badi (författare)
- Hamad Medical Corporation
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- Suhre, Karsten (författare)
- Weill Cornell Medicine, Qatar
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(creator_code:org_t)
- 2022-11-19
- 2022
- Engelska.
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Type 2 diabetes (T2D) has a heterogeneous etiology influencing its progression, treatment, and complications. A data driven cluster analysis in European individuals with T2D previously identified four subtypes: severe insulin deficient (SIDD), severe insulin resistant (SIRD), mild obesity-related (MOD), and mild age-related (MARD) diabetes. Here, the clustering approach was applied to individuals with T2D from the Qatar Biobank and validated in an independent set. Cluster-specific signatures of circulating metabolites and proteins were established, revealing subtype-specific molecular mechanisms, including activation of the complement system with features of autoimmune diabetes and reduced 1,5-anhydroglucitol in SIDD, impaired insulin signaling in SIRD, and elevated leptin and fatty acid binding protein levels in MOD. The MARD cluster was the healthiest with metabolomic and proteomic profiles most similar to the controls. We have translated the T2D subtypes to an Arab population and identified distinct molecular signatures to further our understanding of the etiology of these subtypes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ANDIS
- diabetes
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zaghlool, Shaza ...
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Halama, Anna
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Stephan, Nisha
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Gudmundsdottir, ...
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Gudnason, Vilmun ...
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Jennings, Lori L ...
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visa fler...
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Thangam, Manonan ...
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Ahlqvist, Emma
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Malik, Rayaz A.
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Albagha, Omar M. ...
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Abou‑Samra, Abdu ...
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Suhre, Karsten
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Nature Communica ...
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Lunds universitet