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Community study of ...
Community study of the relative impact of HIV-1 and HIV-2 on intrathoracic tuberculosis
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Seng, R (författare)
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- Gustafson, Per (författare)
- Lund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups
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Gomes, VF (författare)
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Vieira, CS (författare)
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Rabna, P (författare)
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Larsen, O (författare)
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Larouze, B (författare)
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Norberg, R (författare)
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Lisse, IM (författare)
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Samb, B (författare)
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visa färre...
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: AIDS. - 1473-5571. ; 16:7, s. 1059-1066
- Relaterad länk:
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http://www.aidsonlin...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: HIV-1 infection is associated with an increased incidence of and mortality from tuberculosis. Few community studies have examined the effect of HIV-2 on tuberculosis. Methods: We investigated the association between HIV-1, HIV-2 and active tuberculosis in four districts (population 42 709) in Bissau, capital of Guinea-Bissau, with the highest known seroprevalence of HIV-2 infection in the world. From May 1996 to June 1998, tuberculosis surveillance and active case finding among contacts was conducted. Patients were HIV-tested, given specific tuberculosis treatment for 8 months and followed regarding mortality. Simultaneously, an HIV sero-survey was performed in a random sample of 1748 permanent residents. Results: During a 25-month period, 366 tuberculosis cases were identified. After excluding cases among visitors to the area, and adjusting for age, the incidence of tuberculosis was 18.3 times higher (95% CI 12.9-26.0) among HIV-1-positive individuals, 13.7 times higher (9.0-20.7) among dually infected (HIV-1 and HIV-2), and 3.0 times higher (2.1-4.3) among HIV-2-infected compared with HIV-negative individuals. HIV-1 and dually infected tuberculosis patients had a higher mortality rate than HIV-negative tuberculosis patients [mortality ratio (MR) 2.68; CI 1.11 -6.48 and 2.89; CI 1.13-7.39, respectively]. The survival of HIV-2-positive tuberculosis patients was similar to that of HIV-negative tuberculosis patients (MR 1.19; CI 0.46-3.06). Conclusion: The presence of HIV-2 infection increases the incidence of tuberculosis compared with that in non-HIV-infected individuals, but does not affect tuberculosis-related mortality in the short term. In contrast, the presence of HIV-1 infection, alone or with HIV-2, has a several-fold greater impact on both the incidence of and mortality from tuberculosis. (C) 2002 Lippincott Williams Wilkins.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- co-infection
- HIV-1
- HIV-2
- tuberculosis
- mortality
- incidence
- Africa
- community
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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AIDS
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Seng, R
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Gustafson, Per
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Gomes, VF
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Vieira, CS
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Rabna, P
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Larsen, O
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visa fler...
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Larouze, B
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Norberg, R
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Lisse, IM
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Samb, B
-
visa färre...
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