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Endocytotic activit...
Endocytotic activity of mouse skeletal muscle fibres after long-term denervation
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- Vult von Steyern, Fredrik (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Libelius, Rolf (author)
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Lawoko, Grace (author)
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Tågerud, Sven (author)
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(creator_code:org_t)
- 1994
- 1994
- English.
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In: Journal of the Neurological Sciences. - 1878-5883. ; 125:2, s. 147-152
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http://dx.doi.org/10...
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Abstract
Subject headings
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- The endocytotic activity of skeletal muscle fibres and its relation to the denervated endplate region has been studied using horseradish peroxidase (HRP) as marker for endocytosis. In muscles denervated for a short time period (10-20 days) HRP-uptake occurred in small segments of the muscle fibres near the centre of the muscle (endplate region). After long-term denervation (6-12 months) similar segments with high endocytotic activity were seen preferentially in more peripheral parts of the muscle fibres. Ultrastructural characteristics of segments with high endocytotic activity from long-term denervated muscle fibres include a proliferating transverse tubular system, HRP-containing bodies of different sizes with some very large vacuoles extending over several sarcomeres. These characteristics are similar to those described previously for HRP-uptake in the endplate region of short-term denervated muscle (Tagerud et al., J. Neurol. Sci., 75 (1986) 141) except that no recognizable endplate structures were observed in the present study. The results are discussed in relation to the fate of the denervated endplate and the receptive capacity for synapse formation in long-term denervated muscle.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Keyword
- Endocytosis
- Muscle
- skeletal
- Denervation
- Endplate
- Exocytosis
- Lysosomes
- Reinnervation
Publication and Content Type
- art (subject category)
- ref (subject category)
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