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Consumption of Fish...
Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort
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- Aglago, Elom K. (författare)
- International Agency for Research on Cancer, World Health Organization
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- Huybrechts, Inge (författare)
- International Agency for Research on Cancer, World Health Organization
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- Murphy, Neil (författare)
- International Agency for Research on Cancer, World Health Organization
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- Casagrande, Corinne (författare)
- International Agency for Research on Cancer, World Health Organization,Aarhus University
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- Nicolas, Genevieve (författare)
- International Agency for Research on Cancer, World Health Organization
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- Pischon, Tobias (författare)
- Max Delbrück Center for Molecular Medicine (MDC)
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- Fedirko, Veronika (författare)
- Emory University Rollins School of Public Health
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- Severi, Gianluca (författare)
- University of Paris-Saclay
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- Boutron-Ruault, Marie Christine (författare)
- University of Paris-Saclay
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- Fournier, Agnès (författare)
- University of Paris-Saclay
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- Katzke, Verena (författare)
- German Cancer Research Centre
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Olsen, Anja (författare)
- Danish Cancer Society
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- Tjønneland, Anne (författare)
- Danish Cancer Society,University of Copenhagen
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- Dahm, Christina C. (författare)
- Aarhus University
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- Overvad, Kim (författare)
- Aalborg University Hospital,Aarhus University
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- Lasheras, Cristina (författare)
- University of Oviedo
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- Agudo, Antonio (författare)
- Catalan Institute of Oncology,L'Hospitalet de Llobregat, Barcelona
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- Sánchez, Maria Jose (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Amiano, Pilar (författare)
- Biodonostia Health Research Institute
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- Huerta, José Maria (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Perez-Cornago, Aurora (författare)
- University of Oxford
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Karakatsani, Anna (författare)
- National and Kapodistrian University of Athens,International Agency for Research on Cancer, World Health Organization,Aalborg University Hospital
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- Martimianaki, Georgia (författare)
- Hellenic Health Foundation, Athens
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- Palli, Domenico (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Pala, Valeria (författare)
- Istituto Nazionale dei Tumori
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Naccarati, Alessio (författare)
- Italian Institute for Genomic Medicine (IIGM)
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Bueno-de-Mesquita, Bas (författare)
- University of Malaya,University Medical Center Utrecht,National Institute for Public Health and the Environment (RIVM),Imperial College London
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- May, Anne (författare)
- University Medical Center Utrecht
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- Derksen, Jeroen W.G. (författare)
- University Medical Center Utrecht
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- Hellstrand, Sophie (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Ohlsson, Bodil (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Wennberg, Maria, 1974- (författare)
- Umeå universitet,Umeå University,Avdelningen för hållbar hälsa
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- van Guelpen, Bethany (författare)
- Umeå universitet,Umeå University,Onkologi
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- Skeie, Guri (författare)
- UiT The Arctic University of Norway, Tromsø
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- Brustad, Magritt (författare)
- UiT The Arctic University of Norway, Tromsø
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization
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- Cross, Amanda J. (författare)
- Imperial College London
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- Ward, Heather (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Norat, Teresa (författare)
- Imperial College London
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- Chajes, Veronique (författare)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier BV. - 1542-3565 .- 1542-7714. ; 18:3, s. 6-666
- Relaterad länk:
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http://dx.doi.org/10...
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http://www.cghjourna...
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https://www.cghjourn...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background & Aims: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. Results: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80–0.96; Ptrend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82–0.98; Ptrend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83–1.00; Ptrend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78–0.95; Ptrend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18–1.45; Ptrend < .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (Pheterogeneity = .026). Conclusions: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Epidemiologic
- Omega 3
- Seafood
- Tumorigenesis
- Epidemiologic
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Aglago, Elom K.
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Huybrechts, Inge
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Murphy, Neil
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Casagrande, Cori ...
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Nicolas, Genevie ...
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Pischon, Tobias
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visa fler...
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Fedirko, Veronik ...
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Severi, Gianluca
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Boutron-Ruault, ...
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Fournier, Agnès
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Katzke, Verena
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Kühn, Tilman
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Olsen, Anja
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Tjønneland, Anne
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Dahm, Christina ...
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Overvad, Kim
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Lasheras, Cristi ...
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Agudo, Antonio
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Sánchez, Maria J ...
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Amiano, Pilar
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Huerta, José Mar ...
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Ardanaz, Eva
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Perez-Cornago, A ...
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Martimianaki, Ge ...
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Palli, Domenico
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Pala, Valeria
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Tumino, Rosario
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Naccarati, Aless ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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May, Anne
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Derksen, Jeroen ...
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Hellstrand, Soph ...
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Ohlsson, Bodil
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Wennberg, Maria, ...
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van Guelpen, Bet ...
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Skeie, Guri
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Brustad, Magritt
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Weiderpass, Elis ...
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Cross, Amanda J.
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Ward, Heather
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Riboli, Elio
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Norat, Teresa
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Chajes, Veroniqu ...
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Gunter, Marc J.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Clinical Gastroe ...
- Av lärosätet
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Lunds universitet
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Umeå universitet