Sökning: id:"swepub:oai:lup.lub.lu.se:b93eba7f-c17c-4e98-920b-d50e73e29053" >
Updating the Defini...
Updating the Definition of Cancer
-
- Brown, Joel S. (författare)
- H. Lee Moffitt Cancer Center & Research Institute
-
- Amend, Sarah R. (författare)
- Johns Hopkins University School of Medicine
-
- Austin, Robert H. (författare)
- Princeton University
-
visa fler...
-
Gatenby, Robert A. (författare)
-
- Hammarlund, Emma U. (författare)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Molekylär evolution,Forskargrupper vid Lunds universitet,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Molecular Evolution,Lund University Research Groups
-
- Pienta, Kenneth J. (författare)
- Johns Hopkins University School of Medicine
-
visa färre...
-
H Lee Moffitt Cancer Center & Research Institute Johns Hopkins University School of Medicine (creator_code:org_t)
- 2023
- 2023
- Engelska 6 s.
-
Ingår i: Molecular cancer research : MCR. - 1557-3125. ; 21:11, s. 1142-1147
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Most definitions of cancer broadly conform to the current NCI definition: "Cancer is a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body." These definitions tend to describe what cancer "looks like" or "does" but do not describe what cancer "is" or "has become." While reflecting past insights, current definitions have not kept pace with the understanding that the cancer cell is itself transformed and evolving. We propose a revised definition of cancer: Cancer is a disease of uncontrolled proliferation by transformed cells subject to evolution by natural selection. We believe this definition captures the essence of the majority of previous and current definitions. To the simplest definition of cancer as a disease of uncontrolled proliferation of cells, our definition adds in the adjective "transformed" to capture the many tumorigenic processes that cancer cells adopt to metastasize. To the concept of uncontrolled proliferation of transformed cells, our proposed definition then adds "subject to evolution by natural selection." The subject to evolution by natural selection modernizes the definition to include the genetic and epigenetic changes that accumulate within a population of cancer cells that lead to the lethal phenotype. Cancer is a disease of uncontrolled proliferation by transformed cells subject to evolution by natural selection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas