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Biliary and total e...
Biliary and total extrarenal clearance of inulin and iohexol in pigs. A source of error when determining gfr as body clearance.
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- van Westen, Danielle (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups
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- Almén, Torsten (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Chai, Chun-Ming (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups
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- Frennby, Bo (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Radiology Diagnostics, Malmö,Lund University Research Groups
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Månsson, S (författare)
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- Sterner, Gunnar (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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(creator_code:org_t)
- 2002-06-03
- 2002
- Engelska.
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Ingår i: Nephron. - : S. Karger AG. - 0028-2766 .- 1660-8151 .- 2235-3186. ; 91:2, s. 300-307
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biliary clearance, total extrarenal clearance, body and renal clearance of inulin and iohexol were determined in 11 normal and 11 nephrectomized pigs. The biliary clearance of inulin, calculated as biliary excretion divided by the plasma concentration, was 0.04 and 0.01 ml min<sup>–1</sup> 10 kg<sup>–1</sup> and of iohexol 0.21 and 0.1 ml min<sup>–1</sup> 10 kg<sup>–1</sup> , in normal, respectively, nephrectomized pigs (p < 0.05). The extrarenal clearance of inulin, calculated as body minus renal clearance, was 2.7 and 0.7 ml min<sup>–1</sup> 10 kg<sup>–1</sup> and of iohexol 3.7 and 0.7 ml min<sup>–1</sup> 10 kg<sup>–1</sup> in normal, respectively, nephrectomized pigs (p < 0.05). Some hours after injection of the markers their plasma concentrations were much higher in the nephrectomized pigs. This higher plasma concentration was not matched by an equally higher biliary excretion and therefore biliary clearance decreased. The smaller total extrarenal clearance in nephrectomized pigs, i.e. the overestimation of GFR when calculated as body clearance, indicates that this source of error decreases with decreasing renal function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Iohexol: pharmacokinetics
- Inulin: pharmacokinetics
- Inulin: blood
- Glomerular Filtration Rate
- Female
- Contrast Media: pharmacokinetics
- Animal
- Common Bile Duct: metabolism
- Kidney: metabolism
- Kidney: surgery
- Male
- Metabolic Clearance Rate
- Nephrectomy
- Swine
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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