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Similarities and Di...
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS
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- Sajic, Tatjana (författare)
- ETH Zürich
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- Liu, Yansheng (författare)
- Yale University
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- Arvaniti, Eirini (författare)
- ETH Zürich,University of Zurich
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- Surinova, Silvia (författare)
- UCL Cancer Institute
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- Williams, Evan G. (författare)
- ETH Zürich
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- Schiess, Ralph (författare)
- ProteoMediX AG
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- Hüttenhain, Ruth (författare)
- University of California, San Francisco
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- Sethi, Atul (författare)
- Swiss Institute for Bioinformatics (SIB),University Hospital Basel,University of Basel
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- Pan, Sheng (författare)
- University of Texas Health Science Center at Houston
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- Brentnall, Teresa A. (författare)
- University of Washington
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- Chen, Ru (författare)
- University of Washington
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- Blattmann, Peter (författare)
- ETH Zürich
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- Friedrich, Betty (författare)
- ETH Zürich,University of Zurich
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- Niméus, Emma (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Malander, Susanne (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Omlin, Aurelius (författare)
- Bern University Hospital,Kantonsspital St Gallen
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- Gillessen, Silke (författare)
- Kantonsspital St Gallen,Bern University Hospital
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- Claassen, Manfred (författare)
- ETH Zürich
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- Aebersold, Ruedi (författare)
- University of Zurich,ETH Zürich
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 23:9, s. 5-2831
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating blood plasma. Using a proteomic workflow combining N-glycosite enrichment and SWATH mass spectrometry, we generate a data resource of 284 blood samples derived from patients with different types of localized-stage carcinomas and from matched controls. We observe whether the changes in the patient's plasma are specific to a particular carcinoma or represent a generic signature of proteins modified uniformly in a common, systemic response to many cancers. A quantitative comparison of the resulting N-glycosite profiles discovers that proteins related to blood platelets are common to several cancers (e.g., THBS1), whereas others are highly cancer-type specific. Available proteomics data, including a SWATH library to study N-glycoproteins, will facilitate follow-up biomarker research into early cancer detection. Sajic et al. perform a multi-tumor plasma proteomic study in which they enrich and analyze tissue-secreted plasma glycoproteins to examine blood protein changes in early-stage localized cancers. They demonstrate that many proteins secreted upon platelet activation are changed in several tissue carcinomas, whereas others have changes specific to a single carcinoma type.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- blood
- carcinoma
- glycoproteins
- human clinical study
- localized cancer
- secreted
- SWATH-mass spectrometry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Sajic, Tatjana
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Liu, Yansheng
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Arvaniti, Eirini
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Surinova, Silvia
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Williams, Evan G ...
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Schiess, Ralph
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visa fler...
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Hüttenhain, Ruth
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Sethi, Atul
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Pan, Sheng
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Brentnall, Teres ...
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Chen, Ru
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Blattmann, Peter
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Friedrich, Betty
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Niméus, Emma
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Malander, Susann ...
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Omlin, Aurelius
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Gillessen, Silke
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Claassen, Manfre ...
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Aebersold, Ruedi
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cell Reports
- Av lärosätet
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Lunds universitet