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Involvement of sens...
Involvement of sensory nerves in vasodilator responses to acetylcholine and potassium ions in rat hepatic artery
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- Högestätt, Edward D. (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Johansson, Rebecka (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Andersson, David A. (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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- Zygmunt, Peter M. (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Neurofarmakologi och smärta,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Neuropharmacology and pain,Lund University Research Groups
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(creator_code:org_t)
- 2009-01-29
- 2000
- Engelska 6 s.
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Ingår i: British Journal of Pharmacology. - : Wiley. - 0007-1188. ; 130:1, s. 27-32
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- In the presence of ouabain (1 mM), acetylcholine and KCl (5 mM) evoked endothelium-independent relaxations in rat hepatic arteries. Treatment with capsaicin (10 μM), scopolamine (1 μM) or CGRP8-37 (3 μM) prevented these relaxations. Acetylcholine-induced relaxations in intact arterial segments in the presence of indomethacin (10 μM) and N(G)-nitro-L-arginine (0.3 mM) were only partially inhibited by ouabain plus BaCl2 (30 μM). However, ouabain plus BaCl2 almost abolished such relaxations in capsaicin-pre-treated preparations. In arteries without endothelium, the neurosecretagogue α-latrotoxin (1 nM) induced complete relaxations, which were abolished by CGRP8-37 or pre-treatment with capsaicin. α-Latrotoxin also induced a smooth muscle hyperpolarization (12 ± 2 mV), which was abolished by CGRP8-37. The ability of ouabain to disclose a CGRP-mediated neurogenic relaxation must be considered when this agent is used as a pharmacological tool. The results further suggest that CGRP is a nerve-derived hyperpolarizing factor in the rat hepatic artery.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Endothelium-derived hyperpolarizing factor
- Endothelium-derived relaxing factors
- Hyperpolarization
- Membrane potential
- Nitric oxide
- Potassium channels
- Vascular endothelium
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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