Electron Microscopy in Diagnostic Pathology with Reference to Mesenchymal Tumors

• The experience acquired over a period of 15 years of diagnostic electron microscopy of fine needle aspirates and surgical specimens constitutes the base for this thesis. Some of the tumors analyzed represent rare soft tissue tumors, and consequently not very often ultrastructurally described. In locations where sarcomas are rare and unexpected, electron microscopy may contribute to a correct tumor classification when type specific structures are present. Electron microscopic examination is a suitable method to confirm presence of mesenchymal tumor cells in cultures and to compare the morphology in cultures and fresh tumor tissue provided that the ultrastructural features are specific for the tumor in question. Fine needle aspiration together with the use of electron microscopy is a reliable combination in the typediagnosis of small round cell malignant tumors of childhood and adolescence and spindle cell tumors as peripheral nerve sheath tumors, leiomyosarcoma and synovial sarcoma, especially of the monophasic variant. Electron microscopy contributes to the understanding of successive morphologic changes in the dermal microvasculature of Kaposi´s sarcoma. This thesis presents examples that highlight the value of electron microscopy in the multidisciplinary management of musculoskeletal tumors.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

synovial sarcoma

Kaposi´s sarcoma

epithelioid sarcoma

parachordoma

alveolar soft part sarcoma

small cell malignant tumors of childhood and adolescence

cultured cells

surgical specimens

Transmission electron microscopy

fine needle aspiration

General pathology

pathological anatomy

Patologi (allmän)

patologisk anatomi

Publikations- och innehållstyp

dok (ämneskategori)

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